Patents - Global Data - Dimensions
Application
METHODS OF TREATING CANCER WITH A COMBINATION OF AN ANTI-PD-1 ANTIBODY AND AN ANTI-TISSUE FACTOR ANTIBODY-DRUG CONJUGATE
Applicants
- Genmab (Denmark)
- Genmab AS
- MSD International GmbH
[NORA names: Genmab; Private Research; Denmark; Europe, EU; Nordic; OECD]
[NORA names: Genmab; Private Research]
Abstract
The invention provides an anti-PD-1 antibody comprising the complementary determining regions (CDRs) of pembrolizumab in combination with an antibody-drug conjugate that binds to tissue factor (TF) comprising monomethyl auristatin E and the CDRs of tisotumab (e.g., tisotumab vedotin) and their use in methods of treating cancer, such as breast cancer and cervical cancer. The invention also provides compositions and kits comprising the anti-PD-1 antibody comprising the CDRs of pembrolizumab and the antibody-drug conjugate that binds to TF comprising monomethyl auristatin E and the CDRs of tisotumab (e.g., tisotumab vedotin) for use in treating cancer, such as breast cancer and cervical cancer.
Patent Family Records (13)
Methods for treating cancer using a combination of anti-PD-1 antibody and anti-tissue factor antibody-drug conjugate
Genmab (Denmark), Genmab AS アビドイ オイウェイル オー．, アビドイ オイウェイル オー．, カオ アンソニー, (...more)
2024, JP-7460608-B2
METHODS OF TREATING CANCER WITH A COMBINATION OF AN ANTI-PD-1 ANTIBODY AND AN ANTI-TISSUE FACTOR ANTIBODY-DRUG CONJUGATE
Genmab (Denmark), Genmab AS, MSD International GmbH RANGWALA RESHMA ABDULLA, BREIJ ESTHER C W, VERPLOEGEN SANDRA, (...more)
2022, US-20220088191-A1
METHODS OF TREATING CANCER WITH A COMBINATION OF AN ANTI-PD-1 ANTIBODY AND AN ANTI-TISSUE FACTOR ANTIBODY-DRUG CONJUGATE
Genmab (Denmark), Genmab AS, MSD International GmbH, MSD International Holdings GmbH RANGWALA RESHMA ABDULLA, BREIJ ESTHER C W, VERPLOEGEN SANDRA, (...more)
2022, EP-3814379-A4
METHODS OF TREATING CANCER WITH A COMBINATION OF AN ANTI-PD-1 ANTIBODY AND AN ANTI-TISSUE FACTOR ANTIBODY-DRUG CONJUGATE.
GENMAB AS, Genmab (Denmark) VERPLOEGEN SANDRA, GARDAI SHYRA, CAO ANTHONY, (...more)
2021, MX-2020011823-A
Methods of treating cancer using a combination of anti-PD-1 antibody and anti-tissue factor antibody-drug conjugate
GENMAB A, Genmab (Denmark), MSD INT GMBH RANGWALA RESHMA ABDULLA, BREIJ ESTHER C W, VERPLOEGEN SANDRA, (...more)
2021, KR-20210044183-A
Cancer treatment method using a combination of anti-PD-1 antibody and anti-tissue factor antibody-drug conjugate
Genmab (Denmark), Genmab AS アビドイ オイウェイル オー．, アビドイ オイウェイル オー．, カオ アンソニー, (...more)
2021, JP-2021523233-A
METHODS OF TREATING CANCER WITH A COMBINATION OF AN ANTI-PD-1 ANTIBODY AND AN ANTI-TISSUE FACTOR ANTIBODY-DRUG CONJUGATE
Genmab (Denmark), Genmab AS, MSD International GmbH, MSD International Holdings GmbH RANGWALA RESHMA ABDULLA, BREIJ ESTHER C W, VERPLOEGEN SANDRA, (...more)
2021, EP-3814379-A1
method to treat cancer in an individual, and, kit
GENMAB AS, Genmab (Denmark), MSD INT GMBH Anthony CAO, ESTHER C W BREIJ, LEONARDO VIANA NICACIO, (...more)
2021, BR-112020022642-A2
Methods of treating cancer with a combination of an anti-PD-1 antibody and an anti-tissue factor antibody-drug conjugate
GENMAB AS, Genmab (Denmark), MERCK SHARP & DOHME, MSD (United States) RANGWALA RESHMA ABDULLA, BREIJ ESTHER C W, VERPLOEGEN SANDRA, (...more)
2020, TW-202010755-A
METHODS OF TREATING CANCER WITH A COMBINATION OF AN ANTI-PD-1 ANTIBODY AND AN ANTI-TISSUE FACTOR ANTIBODY-DRUG CONJUGATE
GENMAB AS, Genmab (Denmark), MSD INT GMBH RANGWALA RESHMA ABDULLA, BREIJ ESTHER C W, VERPLOEGEN SANDRA, (...more)
2020, SG-11202010993V-A
Methods of treating cancer with a combination of an anti-PD-1 antibody and an anti-tissue factor antibody-drug conjugate
Genmab (Denmark), Genmab AS, MSD International GmbH, MSD International Holdings GmbH RANGWALA RESHMA ABDULLA, BREIJ ESTHER C W, VERPLOEGEN SANDRA, (...more)
2020, AU-2019266203-A1
METHODS OF TREATING CANCER WITH A COMBINATION OF AN ANTI-PD-1 ANTIBODY AND AN ANTI-TISSUE FACTOR ANTIBODY-DRUG CONJUGATE
GENMAB AS, Genmab (Denmark), MERCK SHARP & DOHME, MSD (United States), MSD INT GMBH RANGWALA RESHMA ABDULLA, BREIJ ESTHER C W, VERPLOEGEN SANDRA, (...more)
2019, WO-2019217455-A1
METHODS OF TREATING CANCER WITH A COMBINATION OF AN ANTI-PD-1 ANTIBODY AND AN ANTI-TISSUE FACTOR ANTIBODY-DRUG CONJUGATE
Genmab (Denmark), Genmab AS, MSD International GmbH RANGWALA RESHMA ABDULLA, BREIJ ESTHER C W, VERPLOEGEN SANDRA, (...more)
2019, CA-3099547-A1