Patents - Global Data - Dimensions
Application
Methods of treating cancer with a combination of an anti-PD-1 antibody and an anti-tissue factor antibody-drug conjugate
Applicants
- Genmab (Denmark)
- Genmab AS
- MSD International Holdings GmbH
- MSD International GmbH
[NORA names: Genmab; Private Research; Denmark; Europe, EU; Nordic; OECD]
[NORA names: Genmab; Private Research]
Abstract
The invention provides an anti-PD-l antibody comprising the complementary determining regions (CDRs) of pembrolizumab in combination with an antibody-drug conjugate that binds to tissue factor (TF) comprising monomethyl auristatin E and the CDRs of tisotumab ( e.g., tisotumab vedotin) and their use in methods of treating cancer, such as breast cancer and cervical cancer. The invention also provides compositions and kits comprising the anti- PD-l antibody comprising the CDRs of pembrolizumab and the antibody-drug conjugate that binds to TF comprising monomethyl auristatin E and the CDRs of tisotumab (e.g., tisotumab vedotin) for use in treating cancer, such as breast cancer and cervical cancer.
Patent Family Records (13)
Methods for treating cancer using a combination of anti-PD-1 antibody and anti-tissue factor antibody-drug conjugate
Genmab (Denmark), Genmab AS アビドイ オイウェイル オー．, アビドイ オイウェイル オー．, カオ アンソニー, (...more)
2024, JP-7460608-B2
METHODS OF TREATING CANCER WITH A COMBINATION OF AN ANTI-PD-1 ANTIBODY AND AN ANTI-TISSUE FACTOR ANTIBODY-DRUG CONJUGATE
Genmab (Denmark), Genmab AS, MSD International GmbH RANGWALA RESHMA ABDULLA, BREIJ ESTHER C W, VERPLOEGEN SANDRA, (...more)
2022, US-20220088191-A1
METHODS OF TREATING CANCER WITH A COMBINATION OF AN ANTI-PD-1 ANTIBODY AND AN ANTI-TISSUE FACTOR ANTIBODY-DRUG CONJUGATE
Genmab (Denmark), Genmab AS, MSD International GmbH, MSD International Holdings GmbH RANGWALA RESHMA ABDULLA, BREIJ ESTHER C W, VERPLOEGEN SANDRA, (...more)
2022, EP-3814379-A4
METHODS OF TREATING CANCER WITH A COMBINATION OF AN ANTI-PD-1 ANTIBODY AND AN ANTI-TISSUE FACTOR ANTIBODY-DRUG CONJUGATE.
GENMAB AS, Genmab (Denmark) VERPLOEGEN SANDRA, GARDAI SHYRA, CAO ANTHONY, (...more)
2021, MX-2020011823-A
Methods of treating cancer using a combination of anti-PD-1 antibody and anti-tissue factor antibody-drug conjugate
GENMAB A, Genmab (Denmark), MSD INT GMBH RANGWALA RESHMA ABDULLA, BREIJ ESTHER C W, VERPLOEGEN SANDRA, (...more)
2021, KR-20210044183-A
Cancer treatment method using a combination of anti-PD-1 antibody and anti-tissue factor antibody-drug conjugate
Genmab (Denmark), Genmab AS アビドイ オイウェイル オー．, アビドイ オイウェイル オー．, カオ アンソニー, (...more)
2021, JP-2021523233-A
METHODS OF TREATING CANCER WITH A COMBINATION OF AN ANTI-PD-1 ANTIBODY AND AN ANTI-TISSUE FACTOR ANTIBODY-DRUG CONJUGATE
Genmab (Denmark), Genmab AS, MSD International GmbH, MSD International Holdings GmbH RANGWALA RESHMA ABDULLA, BREIJ ESTHER C W, VERPLOEGEN SANDRA, (...more)
2021, EP-3814379-A1
method to treat cancer in an individual, and, kit
GENMAB AS, Genmab (Denmark), MSD INT GMBH Anthony CAO, ESTHER C W BREIJ, LEONARDO VIANA NICACIO, (...more)
2021, BR-112020022642-A2
Methods of treating cancer with a combination of an anti-PD-1 antibody and an anti-tissue factor antibody-drug conjugate
GENMAB AS, Genmab (Denmark), MERCK SHARP & DOHME, MSD (United States) RANGWALA RESHMA ABDULLA, BREIJ ESTHER C W, VERPLOEGEN SANDRA, (...more)
2020, TW-202010755-A
METHODS OF TREATING CANCER WITH A COMBINATION OF AN ANTI-PD-1 ANTIBODY AND AN ANTI-TISSUE FACTOR ANTIBODY-DRUG CONJUGATE
GENMAB AS, Genmab (Denmark), MSD INT GMBH RANGWALA RESHMA ABDULLA, BREIJ ESTHER C W, VERPLOEGEN SANDRA, (...more)
2020, SG-11202010993V-A
Methods of treating cancer with a combination of an anti-PD-1 antibody and an anti-tissue factor antibody-drug conjugate
Genmab (Denmark), Genmab AS, MSD International GmbH, MSD International Holdings GmbH RANGWALA RESHMA ABDULLA, BREIJ ESTHER C W, VERPLOEGEN SANDRA, (...more)
2020, AU-2019266203-A1
METHODS OF TREATING CANCER WITH A COMBINATION OF AN ANTI-PD-1 ANTIBODY AND AN ANTI-TISSUE FACTOR ANTIBODY-DRUG CONJUGATE
GENMAB AS, Genmab (Denmark), MERCK SHARP & DOHME, MSD (United States), MSD INT GMBH RANGWALA RESHMA ABDULLA, BREIJ ESTHER C W, VERPLOEGEN SANDRA, (...more)
2019, WO-2019217455-A1
METHODS OF TREATING CANCER WITH A COMBINATION OF AN ANTI-PD-1 ANTIBODY AND AN ANTI-TISSUE FACTOR ANTIBODY-DRUG CONJUGATE
Genmab (Denmark), Genmab AS, MSD International GmbH RANGWALA RESHMA ABDULLA, BREIJ ESTHER C W, VERPLOEGEN SANDRA, (...more)
2019, CA-3099547-A1