open access publication

Preprint, 2024

A roadmap towards the synthesis of Life

ChemRxiv, ISSN 2573-2293, 10.26434/chemrxiv-2024-tnx83

Contributors

Kriebisch, Christine M E 0000-0002-9713-0295 [1] Bantysh, Olga [2] Baranda, Lorena [3] Belluati, Andrea 0000-0003-2305-7272 [4] Bertosin, Eva [5] Dai, Kun [6] de Roy, Maria [3] Fu, Hailin [7] Galvanetto, Nicola 0000-0002-0408-1747 [8] Gibbs, Julianne [9] Santhosh Gomez, Samuel [10] Granatelli, Gaetano [10] Griffo, Alessandra [11] Guix, Maria [2] Onur Gurdap, Cenk [12] Harth-Kitzerow, Johannes 0000-0001-5864-2258 [1] Haugerud, Ivar Svalheim 0000-0001-9931-3741 [10] Häfner, Gregor [13] Jaiswal, Pranay [10] Javed, Sadaf [14] Karimi, Ashkan [1] Kato, Shuzo [15] Kriebisch, Brigitte A K 0000-0001-6551-7279 [1] Laha, Sudarshana 0000-0001-8256-0850 [16] Lee, Pao-Wan 0009-0004-1376-9115 [17] Lipinski, Wojciech [14] Matreux, Thomas 0000-0002-1389-7019 [18] Michaels, Thomas [19] Poppleton, Erik [11] Ruf, Alexander [20] Slootbeek, Annemiek D 0000-0002-8950-420X [14] Smokers, Iris B A 0000-0001-7938-1616 [14] Soria-Carrera, Héctor 0000-0002-5823-0314 [1] Sorrenti, Alessandro [2] Stasi, Michele [1] Stevenson, Alisdair [19] Thatte, Advait [10] Tran, Mai [11] Van Haren, Merlijn H I 0000-0003-2281-8834 [14] Vuijk, Hidde Derk [10] Wickham, Shelley [21] Zambrano, Pablo [1] Adamala, Katarzyna [22] Alim, Karen [1] Andersen, Ebbe Sloth 0000-0002-6236-8164 [23] Bonfio, Claudia 0000-0003-4160-1163 [24] Braun, Dieter [20] Frey, Erwin [20] Gerland, Ulrich 0000-0002-0859-6422 [1] Huck, Wilhelm [14] Jülicher, Frank 0000-0003-4731-9185 [16] Laohakunakorn, Nadanai 0000-0002-6446-482X [25] Mahadevan, L. [26] Otto, Sijbren 0000-0003-0259-5637 [27] Saenz, James [28] Schwille, Petra 0000-0002-6106-4847 [29] Göpfrich, Kerstin 0000-0003-2115-3551 [11] Weber, Christoph [10] Boekhoven, Job 0000-0002-9126-2430 [1]

Affiliations

  1. [1] Technical University of Munich
    2. [NORA names: Germany; Europe, EU; OECD];
  2. [2] University of Barcelona
    3. [NORA names: Spain; Europe, EU; OECD];
  3. [3] Johannes Gutenberg University Mainz
    4. [NORA names: Germany; Europe, EU; OECD];
  4. [4] TU Darmstadt
    5. [NORA names: Germany; Europe, EU; OECD];
  5. [5] Delft University of Technology
    6. [NORA names: Netherlands; Europe, EU; OECD];

Abstract

The synthesis of life from non-living matter has captivated scientists for centuries. It is a grand challenge aimed at unraveling the fundamental principles of life and leveraging its unique features, such as resilience, sustainability, and the ability to evolve. Synthetic life holds immense potential in biotechnology, medicine, and materials science. Advancements in synthetic biology, systems chemistry, and biophysics have brought us closer to achieving this ambitious goal. Researchers have successfully assembled cellular components and synthesized biomimetic hardware for synthetic cells, while chemical reaction networks have demonstrated potential for Darwinian evolution. However, numerous challenges persist, including defining terminology and objectives, interdisciplinary collaboration, and addressing ethical aspects and public concerns. Our perspective offers a roadmap toward the engineering of life based on discussions during a two-week workshop with scientists from around the globe.

Keywords

Darwinian evolution, advances, aspects, biology, biophysics, biotechnology, cells, cellular components, century, chemical reaction networks, chemistry, collaboration, components, concerns, discussion, engine of life, engineering, ethical aspects, evolution, features, globe, goal, hardware, interdisciplinary collaboration, life, materials, materials science, matter, medicine, network, non-living matter, objective, perspective, potential, public concern, reaction network, research, resilience, science, scientists, sustainability, synthesis, synthesis of life, synthetic biology, synthetic cells, synthetic life, system, systems chemistry, terminology, two-week workshop, unique features, workshop

Funders

  • Deutsche Forschungsgemeinschaft

Data Provider: Digital Science

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