open access publication

Article, 2024

Oral Anaerobutyricum soehngenii augments glycemic control in type 2 diabetes

iScience, ISSN 2589-0042, Page 110455, 10.1016/j.isci.2024.110455

Contributors

Attaye, Ilias 0000-0001-9166-3229 [1] [2] [3] Witjes, Julia J [1] [2] [3] Koopen, Annefleur M [1] [2] [3] Van Der Vossen, Eduard W J [1] Zwirs, Diona [1] Wortelboer, Koen 0000-0002-3582-0127 [1] [2] [3] Collard, Didier 0000-0001-8572-8751 [1] Kemper, Elles Marleen 0000-0003-2275-1713 [4] Winkelmeijer, Maaike [1] [5] Holst, Jens J. [6] Hazen, Stanley L 0000-0001-7124-6639 [7] Kuipers, Folkert 0000-0003-2518-737X [8] Stroes, Erik S G [1] Groen, Albert Kornelis [1] [5] de Vos, Willem M. [9] [10] Nieuwdorp, Max [1] [5] Herrema, Hilde J 0000-0002-0112-6348 [1] [2] [3] [5]

Affiliations

  1. [1] Department of Vascular Medicine, Amsterdam University Medical Centers;
  2. [2] Amsterdam Cardiovascular Sciences, Diabetes Metabolism, Amsterdam, The Netherlands
    3. [NORA names: Netherlands; Europe, EU; OECD];
  3. [3] Amsterdam Gastroenterology Endocrinology Metabolism, Endocrinology, metabolism and nutrition, Amsterdam, The Netherlands
    4. [NORA names: Netherlands; Europe, EU; OECD];
  4. [4] Amsterdam University Medical Centers
    5. [NORA names: Netherlands; Europe, EU; OECD];
  5. [5] Department of Experimental Vascular Medicine, Amsterdam University Medical Centers,

Abstract

This randomized, double-blind, placebo-controlled trial investigated the impact of 14-day Anaerobutyricum soehngenii L2-7 supplementation on postprandial glucose levels in 25 white Dutch males with type 2 diabetes (T2D) on stable metformin therapy. The primary endpoint was the effect of A. soehngenii versus placebo on glucose excursions and variability as determined by continuous glucose monitoring. Secondary endpoints were changes in ambulatory 24-hours blood pressure; incretins; circulating metabolites and excursions of plasma short-chain fatty acids (SCFA) and bile acids upon a standardized meal. Results showed that A. soehngenii supplementation for 14-days significantly improved glycemic variability and mean arterial blood pressure, without notable changes in SCFA, bile acids, incretin levels, or anthropometric parameters as compared to placebo-treated controls. Although well-tolerated and effective in improving glycemic control in the intervention group, further research in larger and more diverse populations is needed to generalize these findings.

Keywords

A. soehngenii, Anaerobutyricum, Dutch males, Secondary endpoints, T2D, acid, ambulatory 24-hour blood pressure, anthropometric parameters, arterial blood pressure, bile, bile acids, blood pressure, changes, circulating metabolites, continuous glucose monitoring, control, diverse populations, double-blind, effect, endpoint, excursion, fatty acids, findings, glucose, glucose excursions, glucose levels, glucose monitoring, glycemic control, glycemic variability, group, impact, improve glycemic control, incretin, incretin levels, intervention, intervention group, levels, male, meal, metabolites, metformin therapy, monitoring, parameters, placebo, placebo-controlled trial, placebo-treated controls, plasma short-chain fatty acids, population, postprandial glucose levels, pressure, primary endpoint, research, results, short-chain fatty acids, stable metformin therapy, standard meal, supplementation, therapy, trials, type, type 2 diabetes, variables

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