open access publication

Article, 2024

Improving laboratory animal genetic reporting: LAG-R guidelines

Nature Communications, ISSN 2041-1723, Volume 15, 1, Page 5574, 10.1038/s41467-024-49439-y

Contributors

Teboul, Lydia M 0000-0002-2789-8637 (Corresponding author) [1] Amos-Landgraf, James M 0000-0003-2535-7746 [2] Benavides, Fernando J 0000-0003-1275-4320 [3] Birling, Marie-Christine 0000-0002-3372-8108 [4] Brown, Steve D. M. [5] Bryda, Elizabeth C [2] Bunton-Stasyshyn, Rosie K A 0000-0002-1895-2240 [1] Chin, Hsian-Jean 0000-0001-7385-8575 [6] Crispo, Martina 0000-0002-9852-5563 [7] Delerue, Fabien [3] Dobbie, Michael [8] Franklin, Craig L. [2] Füchtbauer, Ernst-Martin [9] Gao, Xiang [10] Golzio, Christelle 0000-0002-4420-3921 [4] Haffner, Rebecca [11] Herault, Yann 0000-0001-7049-6900 [4] Hrabě De Angelis, Martin 0000-0002-7898-2353 [12] [13] [14] Lloyd, Kevin C Kent [15] Magnuson, Terry R [16] Montoliu, Lluı S 0000-0003-3941-1176 [17] [18] Murray, Stephen A. [19] Nam, Ki-Hoan [20] Nutter, Lauryl M J 0000-0001-9619-146X [21] Pailhoux, Eric A [22] Pardo-Manuel De Villena, Fernando [16] [23] Peterson, Kevin [19] Reinholdt, Laura G 0000-0003-4054-4048 [19] Sedlacek, Radislav [24] Seong, Je Kyung 0000-0003-1177-6958 [25] Shiroishi, Toshihiko 0000-0003-0535-2016 [26] Smith, Cynthia [19] Takeo, Toru 0000-0002-8103-651X [27] Tinsley, Louise [1] Vilotte, Jean-Luc 0000-0003-4623-0584 [28] Warming, Søren 0000-0002-5721-0741 [29] Wells, Sara [1] [30] Whitelaw, Christopher Bruce Alexander 0000-0002-2918-1605 [31] Yoshiki, Atsushi 0000-0002-9450-5151 [26] Pavlovic, Guillaume 0000-0001-9122-4592 (Corresponding author) [4]

Affiliations

  1. [1] MRC Harwell Institute
    2. [NORA names: United Kingdom; Europe, Non-EU; OECD];
  2. [2] University of Missouri
    3. [NORA names: United States; America, North; OECD];
  3. [3] The University of Texas MD Anderson Cancer Center
    4. [NORA names: United States; America, North; OECD];
  4. [4] Inserm
    5. [NORA names: France; Europe, EU; OECD];
  5. [5] Mouse Clinical Institute
    6. [NORA names: France; Europe, EU; OECD];

Abstract

The biomedical research community addresses reproducibility challenges in animal studies through standardized nomenclature, improved experimental design, transparent reporting, data sharing, and centralized repositories. The ARRIVE guidelines outline documentation standards for laboratory animals in experiments, but genetic information is often incomplete. To remedy this, we propose the Laboratory Animal Genetic Reporting (LAG-R) framework. LAG-R aims to document animals’ genetic makeup in scientific publications, providing essential details for replication and appropriate model use. While verifying complete genetic compositions may be impractical, better reporting and validation efforts enhance reliability of research. LAG-R standardization will bolster reproducibility, peer review, and overall scientific rigor.

Keywords

ARRIVE guidelines, animal studies, animals, arrival, biomedical research community, central repository, challenges, community, composition, data, data sharing, design, documentation standards, documents, efforts, experimental design, experiments, genetic composition, genetic information, genetic makeup, genetic reporters, guidelines, information, laboratory, laboratory animals, makeup, model, model use, nomenclature, peer, peer review, publications, reliability, reliability of research, replication, reports, repository, reproducibility, reproducibility challenges, research, research community, review, rigor, scientific publications, scientific rigor, sharing, standard nomenclature, standards, study, transparent reporting, use, validation efforts, validity

Funders

  • Czech Academy of Sciences
  • National Science and Technology Council
  • Ministry of Education Youth and Sports
  • Office of the Director
  • Agence Nationale de la Recherche

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