Article, 2024

Severe steroid‐related neuropsychiatric symptoms during paediatric acute lymphoblastic leukaemia therapy—An observational Ponte di Legno Toxicity Working Group Study

British Journal of Haematology, ISSN 1365-2141, 0007-1048, 10.1111/bjh.19610

Contributors

Anastasopoulou, Stavroula 0000-0002-4210-0064 (Corresponding author) [1] [2] Swann, Gemma [3] Andrés-Jensen, Liv 0000-0003-3437-8338 [4] Attarbaschi, Andishe 0000-0002-9285-6898 [5] [6] Barzilai-Birenboim, Shlomit 0000-0002-3994-0556 [7] [8] Erdélyi, Dániel János [9] Escherich, Gabriele [10] Hamadeh, Lina [11] Harila, Arja Helena 0000-0003-2767-5828 [12] Lopez-Lopez, Elixabet 0000-0002-5309-3031 [13] [14] Mcgowan, Sheena [3] Möricke, Anja [15] Putti, Caterina [16] Sagi, Judit C 0000-0003-2186-9357 [9] Schmiegelow, Kjeld 0000-0002-0829-4993 [4] [17] Ullrich, Nicole J [18] [19] Van Der Sluis, Inge M 0000-0002-5822-7668 [20] Wahid, Qurat-Ul-Ain [3] Winick, Naomi Joan 0000-0002-6636-3870 [21] Sramkova, Lucie 0000-0002-1035-422X [22] Zalcberg, Yair [8] Zapotocka, Ester [22] Bhojwani, Deepa 0000-0002-7559-7927 [23] [24] Halsey, Christina 0000-0001-5449-5246 [3] Di Legno Neurotoxicity Working Group, the Ponte

Affiliations

  1. [1] Karolinska Institutet
    2. [NORA names: Sweden; Europe, EU; Nordic; OECD];
  2. [2] Karolinska University Hospital
    3. [NORA names: Sweden; Europe, EU; Nordic; OECD];
  3. [3] University of Glasgow
    4. [NORA names: United Kingdom; Europe, Non-EU; OECD];
  4. [4] Rigshospitalet
    5. [NORA names: Capital Region of Denmark; Hospital; Denmark; Europe, EU; Nordic; OECD];
  5. [5] Medical University of Vienna
    6. [NORA names: Austria; Europe, EU; OECD];

Abstract

Steroids are a mainstay in the treatment of acute lymphoblastic leukaemia (ALL) in children and adolescents; however, their use can cause clinically significant steroid-related neuropsychiatric symptoms (SRNS). As current knowledge on SRNS during ALL treatment is limited, we mapped the phenotypes, occurrence and treatment strategies using a database created by the international Ponte di Legno Neurotoxicity Working Group including data on toxicity in the central nervous system (CNS) in patients treated with frontline ALL protocols between 2000 and 2017. Ninety-four of 1813 patients in the CNS toxicity database (5.2%) experienced clinically significant SRNS with two peaks: one during induction and one during intensification phase. Dexamethasone was implicated in 86% of SRNS episodes. The most common symptoms were psychosis (52%), agitation (44%) and aggression (31%). Pharmacological treatment, mainly antipsychotics and benzodiazepines, was given to 87% of patients while 38% were hospitalised due to their symptoms. Recurrence of symptoms was reported in 29% of patients and two previously healthy patients required ongoing pharmacological treatment at the last follow up. Awareness of SRNS during ALL treatment and recommendation on treatment strategies merit further studies and consensus.

Keywords

ALL protocols, Working Group, acute lymphoblastic leukemia, acute lymphoblastic leukemia treatment, adolescents, aggression, agitation, antipsychotics, awareness, benzodiazepines, central nervous system, children, clinic, consensus, data, database, dexamethasone, episodes, group, group study, healthy patients, induction, intensification, intensification phase, knowledge, leukemia, lymphoblastic leukemia, nervous system, neuropsychiatric symptoms, occurrence, patients, peak, pharmacological treatment, phase, phenotype, protocol, psychosis, recommendations, recurrence, recurrence of symptoms, steroids, strategies, study, symptoms, system, toxicity, toxicity database, treatment, treatment of acute lymphoblastic leukemia, treatment strategies, working group study

Funders

  • Glasgow Childrens Hospital Charity
  • Barncancerfonden
  • Children with Cancer UK
  • Cancer Research UK

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