Article, 2024

Homozygosity for R47H in TREM2 and the Risk of Alzheimer’s Disease

New England Journal of Medicine, ISSN 1533-4406, 0028-4793, Volume 390, 23, Pages 2217-2219, 10.1056/nejmc2314334

Contributors

Stefansson, Hreinn 0000-0002-9331-6666 [1] Walters, Guǒmundur Bragi 0000-0002-5415-6487 [1] Sveinbjornsson, Gardar 0000-0003-2429-9468 [1] Tragante, Vinicius 0000-0002-8223-8957 [1] Einarsson, Gudmundur Vikar 0000-0002-1326-2339 [1] Helgason, Hannes [1] Sigurdsson, Asgeir 0000-0002-6911-8248 [1] Beyter, Doruk 0000-0002-3644-5760 [1] Snaebjarnarson, Auðunn Skúta 0000-0002-3496-2991 [1] Ivarsdottir, Erna V 0000-0002-2069-0681 [1] Thorleifsson, Gudmar 0000-0003-4623-9087 [1] Halldorsson, Bjarni V 0000-0003-0756-0767 [1] Norddahl, Gudmundur Logi [1] Styrkarsdottir, Unnur 0000-0001-8146-8278 [1] Sturluson, Arni 0000-0002-5074-5727 [1] Holm, Hilma 0000-0002-9517-6636 [1] Helgason, Agnar [1] Moore, Kristjan [1] Eggertsson, Hannes P [1] Oddsson, Asmundur H 0000-0002-4606-5163 [1] Jonsdottir, Guðrún Áslaug [1] Gunnarsson, Árni Freyr [1] Bjornsdottir, Gyda 0000-0002-8100-0306 [1] Gisladottir, Rosa S 0000-0003-0941-1888 [1] Thorgeirsson, Thorgeir Elís 0000-0002-5149-7040 [1] Skuladottir, Astros Th 0000-0002-5048-0933 [1] Gudbjartsson, Daniel F [1] Sulem, Patrick [1] Jonsson, Palmi V 0009-0002-7174-2274 [2] Thordardottir, Steinunn [2] Snaedal, Jón G [2] Eyjolfsdottir, Helga [3] Creese, Byron 0000-0001-6490-6037 [4] Ballard, Clive [5] Corbett, Anne [5] Vasconcelos Da Silva, Miguel 0000-0002-5188-709X [6] Aarsland, Dag [6] Andreassen, Ole Andreas 0000-0002-4461-3568 [7] Selbæk, Geir 0000-0001-6511-8219 [7] Djurovic, Srdjan [7] Stordal, Eystein [8] Fladby, Thormod [9] Haavik, Jan 0000-0001-7865-2808 [10] Igland, Jannicke [10] Giil, Lasse Melvaer 0000-0003-3520-7530 [11] Eriksson, Sture 0000-0002-3098-3787 [12] Hallmans, Göran 0000-0001-9581-3845 [12] Lövheim, Hugo [12] Lopatko Lindman, Karin [12] Trupp, Miles 0000-0001-8095-053X [12] Forsgren, Lars [12] Werge, Thomas [13] Banasik, Karina [13] Brunak, Søren [13] Ullum, Henrik 0000-0001-7306-9058 [14] Frikke-Schmidt, Ruth 0000-0003-4084-5027 [15] Ostrowski, Sisse Rye 0000-0001-5288-3851 [15] Didriksen, Maria 0000-0002-4856-496X [15] Sørensen, Erik [15] Simonsen, Anja Hviid 0000-0002-5461-162X [15] Nielsen, Jørgen E [15] Waldemar, Gunhilde 0000-0003-0293-220X [15] Pedersen, Ole B [16] Erikstrup, Christian 0000-0001-6551-6647 [17] Knowlton, Kirk U 0000-0003-3544-4130 [18] Nadauld, Lincoln D [18] Stefansson, Kari [1]

Affiliations

  1. [1] deCODE Genetics (Iceland)
    2. [NORA names: Iceland; Europe, Non-EU; Nordic; OECD];
  2. [2] National University Hospital of Iceland
    3. [NORA names: Iceland; Europe, Non-EU; Nordic; OECD];
  3. [3] University of Iceland
    4. [NORA names: Iceland; Europe, Non-EU; Nordic; OECD];
  4. [4] Brunel University London
    5. [NORA names: United Kingdom; Europe, Non-EU; OECD];
  5. [5] University of Exeter
    6. [NORA names: United Kingdom; Europe, Non-EU; OECD];

Abstract

A meta-analysis of tests of association between variants in TREM2 and Alzheimer’s disease showed high risk among R47H homozygotes.

Keywords

Alzheimer, Alzheimer's disease, R47H, TREM2, association, disease, high risk, homozygosity, homozygotes, meta-analysis, risk, risk of Alzheimer's disease, tests of association, variants

Funders

  • National Institute for Health and Care Research
  • The Research Council of Norway
  • UK Research and Innovation
  • Medical Research Council
  • Novo Nordisk (Sweden)
  • Novo Nordisk (Denmark)

Data Provider: Digital Science

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