Article,
Entering the next phase: predicting biological effects of biomolecular condensates
Contributors
Davis, Maria C
0000-0002-1310-8833
[1]
André, Alain A M
0000-0002-4277-9652
[1]
Kjaergaard, Magnus
0000-0002-7020-9366
(Corresponding author)
[1]
[2]
Affiliations
- [1] Aarhus University [NORA names: AU Aarhus University; University; Denmark; Europe, EU; Nordic; OECD];
- [2] Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark; The Danish Research Institute for Translational Neuroscience (DANDRITE), Denmark. Electronic address: magnus@mbg.au.dk. [NORA names: Denmark; Europe, EU; Nordic; OECD]
Abstract
Biomolecular condensates are increasingly recognized as important drivers of cellular function; their dysregulation leads to pathology and disease. We discuss three questions in terms of the impending utility of data-driven techniques to predict condensate-driven biological outcomes, i.e., the impact of cellular state changes on condensates, the effect of condensates on biochemical processes within, and condensate properties that result in cellular dysregulation and disease.
Keywords
biochemical processes,
biological effects,
biological outcomes,
biomolecular condensates,
cellular dysregulation,
cellular functions,
cellular state changes,
changes,
condensation,
condensation properties,
data-driven techniques,
disease,
drivers,
drivers of cellular function,
dysregulation,
effect,
effect of condensation,
function,
i.,
impact,
next phase,
outcomes,
pathology,
phase,
process,
properties,
questions,
state changes,
technique
