open access publication

Article, 2024

Dietary intake of a MFGM/EV-rich concentrate promotes accretion of very long odd-chain sphingolipids and increases lipid metabolic turnover at the whole-body level

Food Research International, ISSN 0963-9969, 1873-7145, Volume 190, Page 114601, 10.1016/j.foodres.2024.114601

Contributors

Sprenger, Richard R 0000-0002-3947-1606 [1] Bilgin, Mesut 0000-0002-5034-8465 [2] Ostenfeld, Marie Stampe [3] Bjørnshave, Ann [3] Rasmussen, Jan Trige 0000-0002-2809-7225 [4] Ejsing, Christer Stenby 0000-0003-4963-0276 (Corresponding author) [1] [5]

Affiliations

  1. [1] University of Southern Denmark
    2. [NORA names: SDU University of Southern Denmark; University; Denmark; Europe, EU; Nordic; OECD];
  2. [2] Lipidomics Core Facility, Danish Cancer Institute, Copenhagen, Denmark.
    3. [NORA names: Denmark; Europe, EU; Nordic; OECD];
  3. [3] Arla Foods (Denmark)
    4. [NORA names: Arla Foods; Private Research; Denmark; Europe, EU; Nordic; OECD];
  4. [4] Aarhus University
    5. [NORA names: AU Aarhus University; University; Denmark; Europe, EU; Nordic; OECD];
  5. [5] European Molecular Biology Laboratory
    6. [NORA names: Germany; Europe, EU; OECD]

Abstract

Lipids from cow milk fat globule membranes (MFGMs) and extracellular vesicles (EVs) are considered beneficial for neurodevelopment, cognitive maintenance and human health in general. Nevertheless, it is largely unknown whether intake of infant formulas and medical nutrition products rich in these particles promote accretion of specific lipids and whether this affects metabolic homeostasis. To address this, we carried out a 16-week dietary intervention study where mice were supplemented with a MFGM/EV-rich concentrate, a control diet supplemented with a whey protein concentrate and devoid of milk lipids, or regular chow. Assessment of commonly used markers of metabolic health, including body weight, glucose intolerance and liver microanatomy, demonstrated no differences across the dietary regimes. In contrast, in-depth lipidomic analysis revealed accretion of milk-derived very long odd-chain sphingomyelins and ceramides in blood plasma and multiple tissues of mice fed the MFGM/EV diet. Furthermore, lipidomic flux analysis uncovered that mice fed the MFGM/EV diet have increased lipid metabolic turnover at the whole-body level. These findings help fill a long-lasting knowledge gap between the intake of MFGM/EV-containing foods and the health-promoting effects of their lipid constituents. In addition, the findings suggest that dietary sphingomyelins or ceramide-breakdown products with very long-chains can be used as structural components of cellular membranes, lipoprotein particles and signaling molecules that modulate metabolic homeostasis and health.

Keywords

accretion, analysis, assessment, blood, blood plasma, body, body weight, cellular membranes, ceramide, chow, cognitive maintenance, components of cellular membranes, concentration, constituents, control diet, cow milk fat globule membrane, cows, diet, dietary intake, dietary intervention study, dietary regimes, dietary sphingomyelin, effect, extracellular vesicles, fat globule membrane, findings, flux analysis, food, formula, gap, globule membrane, glucose, glucose intolerance, health, health-promoting effects, homeostasis, human health, infant formula, intake, intake of infant formula, intervention studies, intolerance, knowledge, knowledge gaps, levels, lipid, lipid constituents, lipidomic analysis, lipoprotein, lipoprotein particles, liver, liver microanatomy, long chains, maintenance, markers, markers of metabolic health, medical nutritional products, membrane, metabolic health, metabolic homeostasis, metabolic turnover, mice, microanatomy, milk fat globule membrane, milk lipids, modulate metabolic homeostasis, molecules, multiple tissues, multiple tissues of mice, nutritional products, particles, plasma, production, protein, regime, regular chow, signal, signaling molecules, sphingolipids, sphingomyelin, structural components, structural components of cellular membranes, study, tissues of mice, turnover, vesicles, weight, whey, whey protein, whole-body level

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