open access publication

Article, 2024

Automatic quantification of REM sleep without atonia reliably identifies patients with REM sleep behavior disorder: a possible screening tool?

Neurological Sciences, ISSN 1126-5442, 1590-1874, 1590-3478, Pages 1-10, 10.1007/s10072-024-07532-6

Contributors

Mancini, Raffaele 0009-0002-7676-8297 [1] Mattioli, Pietro (Corresponding author) [1] [2] Famà, Francesco 0000-0002-9084-9037 [1] [2] Giorgetti, Laura [1] Calizzano, Francesco [1] Nikolic, Miki [3] Frandsen, Rune [3] Jennum, Poul Jørgensen [3] Morbelli, Silvia Daniela 0000-0002-7833-6095 [4] [5] Pardini, Matteo 0000-0002-4740-1982 [1] [2] Arnaldi, Dario 0000-0001-6823-6069 [1] [2]

Affiliations

  1. [1] University of Genoa
    2. [NORA names: Italy; Europe, EU; OECD];
  2. [2] Ospedale Policlinico San Martino
    3. [NORA names: Italy; Europe, EU; OECD];
  3. [3] Rigshospitalet
    4. [NORA names: Capital Region of Denmark; Hospital; Denmark; Europe, EU; Nordic; OECD];
  4. [4] Nuclear Medicine Unit, AOU Città della Salute e della Scienza di Torino, Turin, Italy
    5. [NORA names: Italy; Europe, EU; OECD];
  5. [5] University of Turin
    6. [NORA names: Italy; Europe, EU; OECD]

Abstract

BackgroundREM Sleep Behavior Disorder (RBD) is characterized by absence of physiological muscle atonia during REM sleep (REM sleep without atonia, RWA). Nigro-striatal dopaminergic impairment is a feature of Parkinson disease (PD) and can be identified in prodromal stages as well, such as idiopathic RBD (iRBD). Aims of this study are to explore the efficacy of an automatic RWA quantification in identifying RBD patients and the correlation between RWA and nigro-striatal dopaminergic function.MethodsForty-five iRBD, 46 PD with RBD, 24 PD without RBD patients and 11 healthy controls were enrolled in the Genoa Center (group A) and 25 patients with iRBD (group B) were enrolled in the Danish Center. Group A underwent brain [123I]FP-CIT-SPECT and group B underwent brain [18F]PE2I-PET as measures of nigro-striatal dopaminergic function. Chin muscle activity was recorded in all subjects and analyzed by applying a published automatic algorithm. Correlations between RWA and nigro-striatal dopaminergic function were explored.ResultsThe automatic quantification of RWA significantly differentiated RBD from non-RBD subjects (AUC = 0.86), although with lower accuracy compared with conventional visual scoring (AUC = 0.99). No significant correlation was found between RWA and nigro-striatal dopaminergic function.ConclusionThe automatic quantification of RWA is a reliable tool to identify subjects with RBD and may be used as a first-line screening tool, but without correlations with nigro-striatal dopaminergic functioning.

Keywords

ConclusionThe, Danish, Danish centers, Genoa, No significant correlation, Parkinson, Parkinson's disease, RBD, RBD patients, REM, REM sleep, REM sleep behavior disorder, RWA, ResultsThe, absence, accuracy, activity, algorithm, atonia, automatic algorithm, automatic quantification, behavioral disorders, brain, center, chin, chin muscle activity, control, conventional visual scoring, correlation, disease, disorders, dopaminergic function, dopaminergic impairment, efficacy, function, group, group A, group B, healthy controls, idiopathic RBD, impairment, measurements, muscle activity, muscle atonia, patients, prodromal stage, quantification, quantification of REM sleep, scores, screening, screening tool, significant correlation, sleep, sleep behavior disorder, stage, study, subjects, tools, visual scoring

Funders

  • Ministry of Education, Universities and Research
  • Ministero della Salute

Data Provider: Digital Science

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