Article, 2024
Trends in lung cancer survival in the Nordic countries 1990–2016: The NORDCAN survival studies
Lung Cancer,
ISSN
1872-8332,
0169-5002,
Volume 192,
Page 107826,
10.1016/j.lungcan.2024.107826
Contributors
Lundberg, Frida E
0000-0001-7061-7178
(Corresponding author)
[1]
Ekman, Simon
0000-0002-8343-6226
[1]
[2]
Johansson, Anna Louise Viktoria
[1]
[3]
Engholm, Gerda
0000-0002-5337-6234
[4]
Birgisson, Helgi
[5]
Olafsdottir, Elinborg Jona
[6]
Mørch, Lina Steinrud
0000-0001-6506-2569
[4]
Johannesen, Tom Børge
[3]
Andersson, Therese Marie-Louise
[1]
Pettersson, David
[7]
Seppä, Karri J M
[8]
[9]
Virtanen, Anni
0000-0002-7467-8434
[10]
[11]
Lambe, Mats P
0000-0002-4624-3767
[1]
[12]
Lambert, Paul Christopher
0000-0002-5337-663X
[1]
[13]
Affiliations
- [1]
Karolinska Institutet
[NORA names:
Sweden; Europe, EU; Nordic; OECD];
- [2]
Karolinska University Hospital
[NORA names:
Sweden; Europe, EU; Nordic; OECD];
- [3]
Cancer Registry of Norway
[NORA names:
Norway; Europe, Non-EU; Nordic; OECD];
- [4]
Danish Cancer Society
[NORA names:
DCRC Danish Cancer Society Research Center; Non-Profit Organisations; Denmark; Europe, EU; Nordic; OECD];
- [5]
Icelandic Cancer Registry, Reykjavík, Iceland. Electronic address: helgi.birgisson@krabb.is.
[NORA names:
Iceland; Europe, Non-EU; Nordic; OECD];
(... more)
- [6]
Icelandic Cancer Registry, Reykjavík, Iceland. Electronic address: ella@krabb.is.
[NORA names:
Iceland; Europe, Non-EU; Nordic; OECD];
- [7]
National Board of Health and Welfare
[NORA names:
Sweden; Europe, EU; Nordic; OECD];
- [8]
Finnish Cancer Registry
[NORA names:
Finland; Europe, EU; Nordic; OECD];
- [9]
Tampere University
[NORA names:
Finland; Europe, EU; Nordic; OECD];
- [10]
Helsinki University Hospital
[NORA names:
Finland; Europe, EU; Nordic; OECD];
- [11]
University of Helsinki
[NORA names:
Finland; Europe, EU; Nordic; OECD];
- [12]
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; Regional Cancer Centre Uppsala Central Sweden, Uppsala, Sweden. Electronic address: mats.lambe@ki.se.
[NORA names:
Sweden; Europe, EU; Nordic; OECD];
- [13]
University of Leicester
[NORA names:
United Kingdom; Europe, Non-EU; OECD]
(less)
Abstract
OBJECTIVES: The aim of this study was to evaluate if the previously reported improvements in lung cancer survival were consistent across age at diagnosis and by lung cancer subtypes.
MATERIALS AND METHODS: Data on lung cancers diagnosed between 1990 and 2016 in Denmark, Finland, Iceland, Norway and Sweden were obtained from the NORDCAN database. Flexible parametric models were used to estimate age-standardized and age-specific relative survival by sex, as well as reference-adjusted crude probabilities of death and life-years lost. Age-standardised survival was also estimated by the three major subtypes; adenocarcincoma, squamous cell and small-cell carcinoma.
RESULTS: Both 1- and 5-year relative survival improved continuously in all countries. The pattern of improvement was similar across age groups and by subtype. The largest improvements in survival were seen in Denmark, while improvements were comparatively smaller in Finland. In the most recent period, age-standardised estimates of 5-year relative survival ranged from 13% to 26% and the 5-year crude probability of death due to lung cancer ranged from 73% to 85%. Across all Nordic countries, survival decreased with age, and was lower in men and for small-cell carcinoma.
CONCLUSION: Lung cancer survival has improved substantially since 1990, in both women and men and across age. The improvements were seen in all major subtypes. However, lung cancer survival remains poor, with three out of four patients dying from their lung cancer within five years of diagnosis.
Keywords
Denmark,
Finland,
Iceland,
NORDCAN,
NORDCAN database,
Nordic countries,
Norway,
Sweden,
age,
age groups,
age-specific relative survival,
age-standardised estimates,
age-standardised survival,
age-standardized,
cancer,
cancer subtypes,
cancer survival,
carcinoma,
cells,
countries,
crude probability,
crude probability of death,
data,
database,
death,
diagnosis,
estimated age-standardized,
estimation,
flexible parametric models,
group,
improvement,
life years,
lung,
lung cancer,
lung cancer subtypes,
lung cancer survival,
men,
model,
parametric model,
patients,
pattern of improvement,
patterns,
period,
probability of death,
relative survival,
sex,
small-cell carcinoma,
squamous cells,
study,
subtypes,
survival,
survival studies,
trends,
women,
year of diagnosis,
years
Funders
Data Provider: Digital Science