open access publication

Article, 2024

EADV Task Force Pruritus White Paper on chronic pruritus and chronic prurigo: Current challenges and future solutions

Journal of the European Academy of Dermatology and Venereology, ISSN 1468-3083, 0926-9959, 10.1111/jdv.20102

Contributors

Ständer, Sonja 0000-0003-3612-7786 (Corresponding author) [1] Pereira, Manuel P 0009-0008-0162-0742 [2] [3] Zeidler, Claudia [1] Legat, Franz Josef [4] Misery, Laurent 0000-0001-8088-7059 [5] Lönndahl, Louise 0000-0003-0410-2795 [6] Bewley, Anthony Paul 0000-0003-1195-0290 [7] Brenaut, Emilie 0000-0002-0170-5083 [5] Bobko, Svetlana 0000-0002-4446-2368 [8] Elberling, Jesper 0000-0002-8925-4722 [9] Evers, A. W. M. [10] Garcovich, S. [11] Gieler, Uwe [12] Gonçalo, Margarida M 0000-0001-6842-1360 [13] Kupfer, J. [14] Lambert, J. [15] [16] Lvov, Andrey N [17] [18] Metz, Martin 0000-0002-4070-9976 [2] [3] Michenko, A V Michenko 0000-0002-2985-5729 [17] [18] Papadavid, E. [19] Reich, A. [20] Şavk, Ekin Bozkurt 0000-0002-9318-1378 [21] Schneider, G. [1] Schut, Christina 0000-0001-5366-6285 [14] Serra-Baldrich, Esther 0000-0001-7603-0300 [22] Ständer, H. F. [23] Szepietowski, Jacek Cezary 0000-0003-0766-6342 [24] Wallengren, Joanna 0000-0003-0606-6513 [25] Weisshaar, Elke [26] Augustin, Matthias 0000-0002-4026-8728 [27]

Affiliations

  1. [1] University Hospital Münster
  2. [NORA names: Germany; Europe, EU; OECD];
  3. [2] Charité - University Medicine Berlin
  4. [NORA names: Germany; Europe, EU; OECD];
  5. [3] Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Immunology and Allergology, Berlin, Germany
  6. [NORA names: Germany; Europe, EU; OECD];
  7. [4] Medical University of Graz
  8. [NORA names: Austria; Europe, EU; OECD];
  9. [5] Centre Hospitalier Régional Universitaire de Brest
  10. [NORA names: France; Europe, EU; OECD];

Abstract

Chronic pruritus (CP) is frequent in general medicine and the most common complaint in general dermatology. The prevalence of CP is expected to rise in the future due to the ageing population. The clinical presentation, underlying aetiology and treatment strategy of CP are heterogeneous. Also, individual treatment aims and physical, psychic and economic burdens of patients might vary. Chronic prurigo (CPG) is the most severe disease in the chronic pruritus spectrum, being associated with long-standing scratch-induced skin lesions and a therapy refractory itch-scratch-cycle. It is thus important to raise disease awareness for CP and CPG in the general public and among decision-makers in the health system. Further, there is a need to support a rational clinical framework to optimize both diagnostics and therapeutics. Currently, there is still a shortcoming regarding approved therapies and understanding CP/CPG as severe medical conditions. Therefore, the EADV Task Force Pruritus decided to publish this white paper based on several consensus meetings. The group consented on the following goals: (a) ensure that CP is recognized as a serious condition, (b) increase public awareness and understanding of CP and CPG as chronic and burdensome diseases that can greatly affect a person's quality of life, (c) clarify that in most cases CP and CPG are non-communicable and not caused by a psychiatric disease, (d) improve the support and treatment given to patients with CP to help them manage their disease and (e) publicize existing therapies including current guidelines. We aim to point to necessary improvements in access and quality of care directed to decision-makers in health policy, among payers and administrations as well as in practical care.

Keywords

EADV, White Paper, access, administration, aetiology, aging population, awareness, burden of patients, care, cases, cases CP, challenges, chronic prurigo, chronic pruritus, clinical framework, clinical presentation, complaints, conditions, consensus, consensus meeting, decision-making, dermatology, diagnostics, disease, disease awareness, economic burden, economic burden of patients, framework, future solutions, general dermatology, general medicine, general public, goal, group, guidelines, health, health policy, health system, improvement, increase public awareness, individualized treatment, itch-scratch cycle, lesions, life, medical conditions, medicine, meeting, non-communicable, paper, patients, payers, person's quality of life, personal qualities, persons, policy, population, practice care, presentation, prevalence, prevalence of CP, prurigo, pruritus, psychiatric diseases, public awareness, publications, quality, quality of care, quality of life, severe disease, severe medical conditions, skin lesions, solution, spectra, strategies, support, system, therapeutics, therapy, treatment, treatment strategies

Funders

  • Takeda (United States)
  • Eli Lilly (United States)
  • Bayer (United States)
  • AbbVie (United States)
  • MSD (United States)
  • Bausch Health (United States)
  • Amgen (United States)
  • AstraZeneca (United States)
  • Novartis (United States)
  • Johnson & Johnson (United States)
  • Deutsche Forschungsgemeinschaft
  • Bristol-Myers Squibb (United States)
  • Sanofi (United States)
  • Pfizer (United States)

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