open access publication

Article, 2024

Assessing the Impact of Spraying an Enterococcus faecium-Based Probiotic on Day-Old Broiler Chicks at Hatch on the Incidence of Bacterial Chondronecrosis with Osteomyelitis Lameness Using a Staphylococcus Challenge Model

Animals, ISSN 2076-2615, Volume 14, 9, Page 1369, 10.3390/ani14091369

Contributors

Trieu, Anh Dang [1] Anthney, Amanda [1] Alharbi, Khawla 0009-0002-9137-6734 [1] Asnayanti, Andi [1] [2] Meuter, Antoine [3] Alrubaye, Adnan Ali Khalaf 0000-0002-5122-9150 (Corresponding author) [1]

Affiliations

  1. [1] University of Arkansas at Fayetteville
    2. [NORA names: United States; America, North; OECD];
  2. [2] National Agency of Drug and Food Control, Jakarta 10520, Indonesia
    3. [NORA names: Indonesia; Asia, South];
  3. [3] Animal and Plant Health & Nutrition, Novonesis, 2970 Hørsholm, Denmark;, antme@novonesis.com
    4. [NORA names: Denmark; Europe, EU; Nordic; OECD]

Abstract

Bacterial chondronecrosis with osteomyelitis (BCO) lameness is a bone disease characterized by the translocation of bacteria from the gastrointestinal tract, which colonize microfractures in broiler leg bones caused by rapid animal growth rate and weight gain, resulting in lameness. As such, BCO lameness represents a significant challenge for the poultry industry. This study aims to evaluate the effect of spraying broiler chicks on d0 at hatch with an Enterococcus faecium probiotic on the incidence of BCO-induced lameness, utilizing a Staphylococcus aureus challenge model. There were four treatments: (1) negative control (no probiotic + no challenge, NC); (2) positive control (no probiotic + challenge, PC); (3) low dosage (4.0 × 108 CFU/chick + challenge, LOW); and (4) high dosage (2.0 × 109 CFU/chick + challenge, HIGH). On d5, groups two through four were challenged with Staphylococcus aureus through the drinking water at a concentration of 1.0 × 105 CFU/mL. Cumulative lameness incidence was determined through daily evaluations and necropsies conducted on lame birds starting from d22. Data were subjected to a binomial general regression analysis (significant p < 0.05). On d56, the PC group exhibited the highest cumulative lameness incidence (58.0%; p < 0.05), followed by LOW (36.0%), HIGH (28.7%), and NC groups (25.3%), respectively. These results suggest early probiotic application at day-of-hatch successfully reduced the incidence of lameness in challenged birds, thus contributing to understanding of efficient and sustainable broiler production.

Keywords

BCO, D22, D5, Enterococcus, Enterococcus faecium</i> , High, NC group, PC group, analysis, animal growth rate, animals, applications, bacteria, bacterial chondronecrosis, birds, bone, bone disease, broiler chicks, broiler production, broilers, challenge model, challenged birds, challenges, chicks, chondronecrosis, concentration, control, daily evaluation, data, day of hatch, day old broiler chicks, day-old, disease, dosage, drinking, drinking water, effect, evaluation, gain, gastrointestinal tract, general regression analysis, group, growth rate, hatching, higher dosage, impact, incidence, incidence of lameness, industry, lame birds, lameness, lameness incidence, leg bones, low dosage, low-, microfracture, model, necropsy, osteomyelitis, positive control, poultry, poultry industry, probiotic applications, production, rate, regression analysis, results, staphylococci, study, tract, translocation, translocation of bacteria, treatment, water, weight, weight gain

Funders

  • Agricultural Research Service

Data Provider: Digital Science

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