Article, 2024

Curcumin mitigates Aβ33-42 fibril-induced neuronal injury in the hippocampus

Materials Today Physics, ISSN 2542-5293, Volume 44, Page 101436, 10.1016/j.mtphys.2024.101436

Contributors

Chen, Ziyu 0009-0009-2977-146X [1] [2] Xia, Dan 0000-0001-7892-7381 (Corresponding author) [1] Liang, Xiaoteng [1] [2] Liu, Qian [3] Li, Jianwei [1] [2] Li, Qiang 0000-0003-1056-4152 (Corresponding author) [2] Dong, Ming-Dong 0000-0002-2025-2171 (Corresponding author) [3]

Affiliations

  1. [1] Hebei University of Technology
    2. [NORA names: China; Asia, East];
  2. [2] Shandong University
    3. [NORA names: China; Asia, East];
  3. [3] Aarhus University
    4. [NORA names: AU Aarhus University; University; Denmark; Europe, EU; Nordic; OECD]

Abstract

The targeted removal of Aβ33-42 accumulation in vivo emerges as a promising strategy for Alzheimer's disease (AD) treatment, offering potential avenues for the development of innovative anti-AD therapeutics. In this study, the effect of curcumin (Cur) with AD therapeutic potential on the cellular mechanical properties of Aβ33-42 fibril-induced neurons injury in the hippocampus of mice has been explored. The results showed that Cur had no obvious toxicity and side effects on neuronal cells and could significantly inhibit Aβ33-42-induced cell damage and improve cell survival. The measurements of cell mechanical properties revealed that Cur could restore the mechanical properties of damaged cells to a large extent. In addition, the inhibition mechanism of Cur on Aβ33-42-induced damage cell model was explained, which provides clues for the development of new drugs for the AD treatment.

Keywords

AB33, AD treatment, Alzheimer, Alzheimer's disease, Cur, accumulation in vivo, anti-AD therapeutics, avenues, cell damage, cell mechanical properties, cell model, cell survival, cells, cellular mechanical properties, curcumin, damage, damage cell model, damaged cells, development, disease, drug, effect, effects of curcumin, hippocampus, hippocampus of mice, improve cell survival, inhibition, inhibition mechanism, injury, measurement of cell mechanical properties, measurements, mechanical properties, mechanism of Cur, mice, model, neuronal cells, neuronal injury, potential, potential avenues, properties, results, side, side effects, study, survival, targeted removal, therapeutic potential, therapeutics, toxicity, treatment

Funders

  • National Natural Science Foundation of China
  • Danish Agency for Science and Higher Education
  • European Commission

Data Provider: Digital Science

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