Article, 2024

Diabetes and the gastrointestinal tract

Medicine, ISSN 1878-9390, 1357-3039, Volume 52, 5, Pages 304-310, 10.1016/j.mpmed.2024.02.013


Wegeberg, Anne-Marie Langmach 0000-0002-8323-4843 [1] [2] Brock, Christina 0000-0002-3381-1884 [1] [2]


  1. [1] Aalborg University
  2. [NORA names: AAU Aalborg University; University; Denmark; Europe, EU; Nordic; OECD];
  3. [2] Anne-Marie Wegeberg Msc Phd is a Research Fellow, with interest in gastroenteropathy in diabetes. Competing interests: none declared


Gastrointestinal (GI) complications of diabetes mellitus are common and substantially decrease health-related quality of life. Diabetes can affect every part of the GI tract, from the oesophagus to the rectum, and causes various symptoms, including reflux, heartburn, nausea, vomiting, abdominal pain, diarrhoea and constipation. Diabetes-induced GI complications are collectively referred to as diabetic gastroenteropathy. Over recent years, investigation of the underlying pathogenesis of diabetes-induced GI complications has provided objective evidence of abnormalities in the enteric nervous system, essential for normal motility within the GI tract. The diagnosis of diabetic gastroenteropathy is complex, and other causes of GI symptoms should be excluded. There is currently no cure for diabetic gastroenteropathy. Hence, treatment goals are to slow progression, relieve symptoms and manage complications. The key is tight glycaemic control, dietary advice and occasionally pharmacological treatment.


GI complications, GI symptoms, GI tract, abdominal pain, abnormalities, advice, complication of diabetes mellitus, complications, constipation, control, cure, decreased health-related quality of life, diabetes, diabetes mellitus, diabetic gastroenteropathy, diagnosis, diarrhea, dietary advice, enteric nervous system, esophagus, evidence, evidence of abnormalities, gastroenteropathy, gastrointestinal (GI, glycaemic control, goal, health-related quality of life, heartburn, investigation, life, mellitus, motility, nausea, nervous system, normal motility, pain, pathogenesis, pharmacological treatment, progression, quality of life, rectum, reflux, slow progression, symptoms, system, tight glycaemic control, tract, treatment, treatment goals, vomiting, years

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