Preprint,
The fluctuation-dissipation theorem and the discovery of distinctive off-equilibrium signatures of brain states
Affiliations
- [1] Institute of Physics Rosario [NORA names: Argentina; America, South];
- [2] National University of Rosario [NORA names: Argentina; America, South];
- [3] University of Buenos Aires [NORA names: Argentina; America, South];
- [4] Pompeu Fabra University [NORA names: Spain; Europe, EU; OECD];
- [5] Aarhus University [NORA names: AU Aarhus University; University; Denmark; Europe, EU; Nordic; OECD];
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Abstract
The brain is able to sustain many different states as shown by the daily natural transitions between wakefulness and sleep. Yet, the underlying complex dynamics of these brain states are essentially in non-equilibrium. Here, we develop a thermodynamical formalism based on the off-equilibrium extension of the fluctuation-dissipation theorem (FDT) together with a whole-brain model. This allows us to investigate the non-equilibrium dynamics of different brain states and more specifically to apply this formalism to wakefulness and deep sleep brain states. We show that the off-equilibrium thermodynamical signatures of brain states are significantly different in terms of the overall level of differential and integral violation of FDT. Furthermore, the framework allows for a detailed understanding of how different brain regions and networks are contributing to the off-equilibrium signatures in different brain states. Overall, this framework shows great promise for characterising and differentiating any brain state in health and disease.