open access publication

Article, 2024

Exploring the Role of Hyaluronic Acid in Reproductive Biology and Beyond: Applications in Assisted Reproduction and Tissue Engineering

Advanced Biology, ISSN 2366-7478, 2701-0198, Volume 8, 6, Page e2300621, 10.1002/adbi.202300621

Contributors

Ghaleno, Leila Rashki 0000-0002-6241-6904 [1] [2] Pennisi, Cristian Pablo 0000-0002-7716-1182 [3] Shahverdi, Abdolhossein H 0000-0002-9615-4586 [2] Dardmeh, Fereshteh 0000-0002-2034-0147 [3] Alipour, Hiva 0000-0002-8500-4208 (Corresponding author) [3] Valojerdi, Mojtaba Rezazadeh (Corresponding author) [2] [4]

Affiliations

  1. [1] Royan Institute
    2. [NORA names: Iran; Asia, Middle East];
  2. [2] Academic Center for Education, Culture and Research
    3. [NORA names: Iran; Asia, Middle East];
  3. [3] Aalborg University
    4. [NORA names: AAU Aalborg University; University; Denmark; Europe, EU; Nordic; OECD];
  4. [4] Tarbiat Modares University
    5. [NORA names: Iran; Asia, Middle East]

Abstract

Hyaluronic acid (HA) plays a prominent role in various aspects of reproductive biology and assisted reproductive technologies (ART). This review describes the multifaceted influence of HA, ranging from primordial germ cell migration, ovarian follicle development, and ovulation in females to sperm structure, physiology, motility, and capacitation in males. In addition, HA also plays an important role in fertilization and promotes embryo implantation by mediating cellular adhesion and communication within the uterus. Against this physiological background, the review examines the current applications of HA in the context of ART. In addition, the article addresses the emerging field of reproductive tissue engineering, where HA-based hydrogels offer promising perspectives as they can support the development of mature oocytes and spermatogenesis in vitro. Overall, this review highlights the integral role of HA in the intricate mechanisms of reproductive biology and its growing importance for improving ART outcomes and the field of tissue engineering of the reproductive system.

Keywords

ART outcomes, HA-based hydrogels, acid, adhesion, application of HA, applications, article, assistance, assisted reproduction, assisted reproductive technology, background, biology, capacitance, cell migration, cellular adhesion, communication, context, context of assisted reproductive technologies, development, development of mature oocytes, embryo implantation, engineering, females, fertility, field, field of tissue engineering, follicle development, germ cell migration, hyaluronic acid, hydrogels, implantation, improve ART outcomes, influence of HA, integral role, intricate mechanisms, male, mature oocytes, migration, motility, multifaceted influence, oocytes, outcomes, ovarian follicle development, ovulation, physiological background, physiology, primordial germ cell migration, promote embryo implantation, reproduction, reproductive biology, reproductive system, reproductive technology, reproductive tissue engineering, review, role, sperm structure, spermatogenesis, spermatogenesis in vitro, structure, system, technology, tissue, tissue engineering, uterus

Data Provider: Digital Science

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