Article, 2024

Engineered bioadhesive Self-Healing nanocomposite hydrogel to fight infection and accelerate cutaneous wound healing

Chemical Engineering Journal, ISSN 1385-8947, 1873-3212, Volume 489, Page 150992, 10.1016/j.cej.2024.150992

Contributors

Nezhad-Mokhtari, Parinaz 0000-0001-5457-3187 [1] [2] Hamishehkar, Hamed 0000-0001-9905-0662 [1] Farahpour, Mohammad Reza 0000-0001-8631-071X [3] Mehdipour, Ahmad 0000-0002-1112-2439 [1] Rahbarghazi, Reza 0000-0003-3864-9166 [1] Milani, Morteza (Corresponding author) [1] Mehrali, Mehdi 0000-0002-5084-1823 (Corresponding author) [2]

Affiliations

  1. [1] Tabriz University of Medical Sciences
    2. [NORA names: Iran; Asia, Middle East];
  2. [2] Technical University of Denmark
    3. [NORA names: DTU Technical University of Denmark; University; Denmark; Europe, EU; Nordic; OECD];
  3. [3] Islamic Azad University of Urmia
    4. [NORA names: Iran; Asia, Middle East]

Abstract

The emergence of multifunctional wound dressings for cutaneous tissue injuries represents a paradigm shift in wound care, offering advanced solutions that transcend traditional wound protection. Inspired by the recent advances in nano-reinforcement and mussel-inspired chemistry, an innovative bioadhesive self-healing hydrogel was developed using dopamine-grafted oxidized sodium alginate/gelatin containing Myrtus communis L. extract@ZIF-8 NPs (MC@ZIF-8/DA-OSA/Gel) through dual cross-linking. The resulting optimized hydrogel demonstrated good physicochemical, and hemostatic properties, rapid self-repair, and firm adhesion to tissues. In vitro analysis confirmed excellent cytocompatibility and adhesion in cultured fibroblasts. Notably, the incorporation of MC@ZIF-8 NPs into hydrogel enhanced antioxidant and antibacterial activities. Applying the engineered hydrogel at the injury site significantly accelerated the healing process in a mouse model of cutaneous wound injury, as evident in increased cutaneous tissue thickness and improved collagen disposition. Moreover, the local increase of CD31+ cells and COL1A+ strands indicated enhanced vascularization, and fibroblast proliferation compared to the other groups. Overall, our results demonstrate the potential efficacy of the engineered system as an advanced wound-covering material, suggesting it could be effective for treating various forms of acute and chronic wounds as well.

Keywords

CD31+ cells, NPs, accelerated cutaneous wound healing, activity, adhesion, advanced solutions, alginate/gelatin, analysis, antibacterial activity, care, cells, chemistry, chronic wounds, collagen disposition, cross-linking, cultured fibroblasts, cutaneous tissue injury, cutaneous wound healing, cytocompatibility, disposition, dressing, efficacy, emergency, engineered hydrogels, engineering systems, enhanced vascularization, excellent cytocompatibility, fibroblast proliferation, fibroblasts, fight infection, firm adhesion, form, group, healing, healing process, hemostatic properties, hydrogels, in vitro analysis, incorporation, infection, injury, injury site, local increase, materials, mice, mouse model, multifunctional wound dressing, mussel-inspired chemistry, nano-reinforcements, nanocomposite hydrogels, optimized hydrogel, paradigm, paradigm shift, process, proliferation, properties, protection, results, self-healing hydrogels, self-healing nanocomposite hydrogels, self-repair, shift, sites, sodium alginate/gelatin, solution, strands, system, thickness, tissue, tissue injury, tissue thickness, treat various forms, vascularization, wound, wound care, wound dressing, wound healing, wound injury, wound protection

Funders

  • Novo Nordisk Foundation
  • The Velux Foundations

Data Provider: Digital Science

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