open access publication

Article, 2024

Preoperative localization of water clear cell giant parathyroid adenoma: A case report

Radiology Case Reports, ISSN 1930-0433, Volume 19, 6, Pages 2492-2497, 10.1016/j.radcr.2024.03.026

Contributors

Gossili, Farid 0000-0003-4029-3197 (Corresponding author) [1] [2] [3] Gauduseviciene, Simona [3] Erentaite, Daiva [3] Iversen, Peter [4] Almasi, Charlotte Elberling [3]

Affiliations

  1. [1] Aalborg University
    2. [NORA names: AAU Aalborg University; University; Denmark; Europe, EU; Nordic; OECD];
  2. [2] Regionshospitalet Viborg
    3. [NORA names: Central Denmark Region; Hospital; Denmark; Europe, EU; Nordic; OECD];
  3. [3] Aalborg University Hospital
    4. [NORA names: North Denmark Region; Hospital; Denmark; Europe, EU; Nordic; OECD];
  4. [4] Aarhus University Hospital
    5. [NORA names: Central Denmark Region; Hospital; Denmark; Europe, EU; Nordic; OECD]

Abstract

Primary hyperparathyroidism commonly results from a solitary parathyroid adenoma. A water clear cell parathyroid adenoma represents a rare histological variant. This report presents the challenges of preoperative detection of a giant parathyroid adenoma, which was of the water clear cell variant. A case of severe hypercalcemia in a patient without clinical symptoms and equivocal findings on standard imaging modalities, in which the use of [11C]C-Methionine PET/CT facilitated the preoperative detection of a giant parathyroid adenoma. Histopathological examination confirmed the diagnosis of a water clear cell giant parathyroid adenoma following surgical excision. These findings highlight the significance of advanced imaging techniques in the detection and management of a rare form of parathyroid adenoma.

Keywords

PET/CT, adenomas, advanced imaging techniques, case of severe hypercalcemia, case report, cases, cell variant, clear cell variant, clinical symptoms, detection, diagnosis, equivocal findings, examination, excision, findings, form, giant parathyroid adenoma, histological variants, histopathological examination, hypercalcemia, hyperparathyroidism, images, imaging modalities, imaging techniques, management, modalities, parathyroid adenoma, patients, preoperative detection, primary hyperparathyroidism, rare form, reports, severe hypercalcemia, significance, solitary parathyroid adenoma, surgical excision, symptoms, technique, variants, water, water-clear cell parathyroid adenoma

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