open access publication

Article, 2024

Focusing on earlier diagnosis of Alzheimer's disease

Future Neurology, ISSN 1748-6971, 1479-6708, Volume 19, 1, Page 2337452, 10.2217/fnl-2023-0024

Contributors

Frederiksen, Kristian Steen 0000-0001-5124-4417 (Corresponding author) [1] [2] Arus, Xavier Morato [3] [4] Zetterberg, Henrik 0000-0003-3930-4354 [5] [6] [7] [8] [9] [10] Gauthier, Serge [11] Boada, Mercè 0000-0003-2617-3009 [3] [4] [12] Pytel, Vanesa Verónica 0000-0002-2518-338X [3] [4] Hahn-Pedersen, Julie Hviid 0000-0001-8187-7047 [13] Tarazona, Luis Rafael Solís 0000-0002-0921-3745 [13] Mattke, Soeren 0000-0003-4666-9132 [14]

Affiliations

  1. [1] Danish Dementia Research Centre
    2. [NORA names: Capital Region of Denmark; Hospital; Denmark; Europe, EU; Nordic; OECD];
  2. [2] University of Copenhagen
    3. [NORA names: KU University of Copenhagen; University; Denmark; Europe, EU; Nordic; OECD];
  3. [3] Ace Alzheimer Center Barcelona, 08028, Barcelona, Spain; Universitat Internacional de Catalunya-Barcelona, 08017, Barcelona, Spain
    4. [NORA names: Spain; Europe, EU; OECD];
  4. [4] Universitat Internacional de Catalunya
    5. [NORA names: Spain; Europe, EU; OECD];
  5. [5] Hong Kong University of Science and Technology
    6. [NORA names: China; Asia, East];

Abstract

Alzheimer's disease (AD) is considered a continuum, progressing from preclinical disease to mild cognitive impairment (MCI) as an early stage, before reaching clinically apparent dementia. Although it is difficult to assess the potential impairments in performance of patients with MCI due to AD, this condition should be diagnosed as early as possible so that, by means of early interventions, patients can maintain their quality of life longer. Healthcare systems should support primary care physicians in their effort to identify patients with MCI due to AD and refer patients to memory clinics and specialists who can provide a reliable diagnosis and initiate appropriate disease management. This review discusses the benefits of earlier AD diagnosis, along with potential challenges and future directions.

Keywords

AD diagnosis, Alzheimer, Alzheimer's disease, apparent dementia, benefits, care physicians, challenges, clinic, clinically apparent dementia, cognitive impairment, conditions, continuum, dementia, diagnosis, diagnosis of Alzheimer's disease, direction, disease, disease management, early intervention, early stages, future directions, healthcare, healthcare system, impairment, intervention, life, management, memory clinic, mild cognitive impairment, patients, performance, performance of patients, physicians, potential challenges, potential impairment, primary care physicians, quality, quality of life, review, specialists, stage, system

Funders

  • Novo Nordisk (Denmark)

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