open access publication

Article, 2024

A semiparametric model for the cause-specific hazard under risk proportionality

Computational Statistics & Data Analysis, ISSN 1872-7352, 0167-9473, Volume 195, Page 107953, 10.1016/j.csda.2024.107953

Contributors

Lo, Simon Ming Sum 0000-0003-1273-4645 [1] Wilke, Ralf Andreas 0000-0002-6105-6345 (Corresponding author) [2] Emura, Takeshi [3]

Affiliations

  1. [1] United Arab Emirates University
  2. [NORA names: United Arab Emirates; Asia, Middle East];
  3. [2] Copenhagen Business School
  4. [NORA names: CBS Copenhagen Business School; University; Denmark; Europe, EU; Nordic; OECD];
  5. [3] Research Organization of Information and Systems
  6. [NORA names: Japan; Asia, East; OECD]

Abstract

Semiparametric Cox proportional hazards models enjoy great popularity in empirical survival analysis. A semiparametric model for cause-specific hazards under a proportionality restriction across risks is considered, which has desired practical properties such as estimation by partial likelihood and an analytical solution for the copula-graphic estimator. The cause-specific and marginal hazards are shown to share functional form restrictions in this case. The model for the cause-specific hazard can be used for inference about parametric restrictions on the marginal hazard without the risk of misspecifying the latter and without knowing the risk dependence. After the class of parametric marginal hazards has been determined, it can be estimated in conjunction with the degree of risk dependence. Finite sample properties are investigated with simulations. An application to employment duration demonstrates the practicality of the approach.

Keywords

Cox proportional hazards models, analysis, analytical solution, approach, cases, cause-specific, cause-specific hazards, conjunction, copula-graphic estimator, degree, dependence, duration, employment, employment duration, estimation, finite sample properties, functional form restrictions, hazard, hazards model, inference, likelihood, marginal hazard, model, partial likelihood, practice, properties, proportion, proportional hazards model, restriction, risk, risk dependence, risk proportion, sample properties, semiparametric Cox proportional hazards model, semiparametric model, simulation, solution, survival analysis

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