open access publication

Article, 2024

The outcomes measured and reported in observational studies of incidental and untreated intracranial meningioma: A systematic review

Neuro-Oncology Advances, ISSN 2632-2498, 0801-3284, Volume 6, 1, Page vdae042, 10.1093/noajnl/vdae042

Contributors

Millward, Christopher Paul (Corresponding author) [1] [2] Islim, Abdurrahman Ismail 0000-0001-9621-043X [1] [2] Armstrong, Terri S 0000-0002-2414-0492 [3] Barrington, Heather [1] Bell, Sabrina [4] Brodbelt, Andrew R [1] [2] Bulbeck, Helen [5] Dirven, Linda 0000-0001-9157-9895 [6] [7] Grundy, Paul L [8] Javadpour, Mohsen 0000-0001-9836-1741 [9] Keshwara, Sumirat M 0000-0001-5390-9996 [1] [2] Koszdin, Shelli Diane [10] Marson, Anthony Guy 0000-0002-6861-8806 [1] [2] McDermott, Michael W [11] Meling, Torstein Ragnar 0000-0001-6595-0873 [12] Oliver, Kathy [13] Plaha, Puneet 0000-0003-3103-6359 [14] Preusser, Matthias [15] Santarius, Thomas [16] Srikandarajah, Nisaharan 0000-0001-9578-508X [1] [2] Taphoorn, Martin J B [6] [7] Turner, Carole [16] Watts, Colin [17] Weller, Michael [18] Williamson, Paula R [1] Zadeh, Gelareh [19] Najafabadi, Amir H Zamanipoor [7] Jenkinson, Michael David 0000-0003-4587-2139 [1] [2] Aldape, Kenneth Islim, Abdurrahman I Au, Karolyn Barnhartz-Sloan, Jill Bi, Wenya Linda Behling, Felix Brastianos, Priscilla K Brodie, Chaya Butowski, Nicholas Carlotti, Carlos Castro, Ana Cohen-Gadol, Aaron Couce, Marta Cusimano, Michael D DiMeco, Francesco Drummond, Katharine Dunn, Ian F Erker, Craig Felicella, Michelle Fountain, Daniel M Galanis, Evanthia Galldiks, Norbert 0000-0002-2485-1796 Giannini, Caterina Goldbrunner, Roland Griffith, Brent Hashizume, Rintaro Hanemann, Clemens Oliver 0000-0002-1951-1025 Herold-Mende, Christel Hnenny, Luke Horbinski, Craig Huang, Raymond Y James, David Jenkinson, Michael D Jungk, Christine Jungwirth, Gerhard Kaufmann, Timothy J Krischek, Boris Kurz, Sylvia Lachance, Daniel Lafougère, Christian Lamszus, Katrin Lee, Ian Liu, Jeff C Makarenko, Serge Malta, Tathiana Mamatjan, Yasin Mansouri, Alireza Mawrin, Christian McDermott, Michael Millward, Christopher P Moliterno-Gunel, Jennifer Morokoff, Andrew Munoz, David Nassiri, Farshad Noushmehr, Houtan Ng, Ho-Keung Perry, Arie Pirouzmand, Farhad Poisson, Laila M Pollo, Bianca Ragunathan, Aditya Raleigh, David Renovanz, Mirjam Ricklefs, Franz Sahm, Felix Saladino, Andrea Santacroce, Antonio Santarius, Thomas Schittenhelm, Jens Schichor, Christian Schultz, David Schmidt, Nils O Selman, Warren Shih, Helen Sloan, Andrew Spears, Julian Snuderl, Matija 0000-0003-0752-0917 Snyder, James Suppiah, Suganth Sulman, Erik Tabatabai, Ghazaleh Tatagiba, Marcos Timmer, Marco Tirapelli, Daniela Tonn, Joerg-Chrsitian Tsang, Derek Vogelbaum, Michael A von Deimling, Andreas Walbert, Tobias Walling, Simon Wang, Justin Wen, Patrick Y Westphal, Manfred Workewych, Adriana M 0000-0002-9264-2099 Yip, Stephen Zada, Gabriel Zadeh, Gelareh Zherebitskiy, Viktor

Affiliations

  1. [1] University of Liverpool
    2. [NORA names: United Kingdom; Europe, Non-EU; OECD];
  2. [2] Walton Centre
    3. [NORA names: United Kingdom; Europe, Non-EU; OECD];
  3. [3] Center for Cancer Research
    4. [NORA names: United States; America, North; OECD];
  4. [4] Brain Tumour Charity
    5. [NORA names: United Kingdom; Europe, Non-EU; OECD];
  5. [5] Brainstrust – The Brain Cancer People, Isle of Wight, UK
    6. [NORA names: United Kingdom; Europe, Non-EU; OECD];

Abstract

Background: The clinical management of patients with incidental intracranial meningioma varies markedly and is often based on clinician choice and observational data. Heterogeneous outcome measurement has likely hampered knowledge progress by preventing comparative analysis of similar cohorts of patients. This systematic review aimed to summarize the outcomes measured and reported in observational studies. Methods: A systematic literature search was performed to identify published full texts describing active monitoring of adult cohorts with incidental and untreated intracranial meningioma (PubMed, EMBASE, MEDLINE, and CINAHL via EBSCO, completed January 24, 2022). Reported outcomes were extracted verbatim, along with an associated definition and method of measurement if provided. Verbatim outcomes were de-duplicated and the resulting unique outcomes were grouped under standardized outcome terms. These were classified using the taxonomy proposed by the "Core Outcome Measures in Effectiveness Trials" (COMET) initiative. Results: Thirty-three published articles and 1 ongoing study were included describing 32 unique studies: study designs were retrospective n = 27 and prospective n = 5. In total, 268 verbatim outcomes were reported, of which 77 were defined. Following de-duplication, 178 unique verbatim outcomes remained and were grouped into 53 standardized outcome terms. These were classified using the COMET taxonomy into 9 outcome domains and 3 core areas. Conclusions: Outcome measurement across observational studies of incidental and untreated intracranial meningioma is heterogeneous. The standardized outcome terms identified will be prioritized through an eDelphi survey and consensus meeting of key stakeholders (including patients), in order to develop a Core Outcome Set for use in future observational studies.

Keywords

COMET taxonomy, Core Outcome Measures, activity monitoring, adult cohort, analysis, area, article, choice, clinical management, clinical management of patients, clinician's choice, cohort, cohort of patients, comet, comparative analysis, consensus, consensus meeting, core, core area, core outcome set, data, de-duplication, definition, design, domain, eDelphi survey, effect, effectiveness trial, full-text, heterogeneous outcome measures, initiation, intracranial meningiomas, knowledge, knowledge progress, literature search, management of patients, measurements, meeting, meningiomas, method, method of measurement, observational data, observational study, outcome domains, outcome measures, outcome set, outcome terms, outcomes, patients, progression, published articles, published full-text, review, search, sets, stakeholders, study, study design, survey, systematic literature search, systematic review, taxonomy, term, text, trials, unique outcomes, verbatim outcomes

Funders

  • Brain Tumour Charity

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