Article, 2024

Carnosine facilitates lysosomal release of inhibitors of T cell surveillance

Cell Metabolism, ISSN 1550-4131, 1932-7420, Volume 36, 3, Pages 461-462, 10.1016/j.cmet.2024.02.003

Contributors

Swietach, Pawel Dominik 0000-0002-9945-9473 (Corresponding author) [1] Jäättelä, Marja Helena 0000-0001-5950-7111 [2] Pillon-Thomas, Shari [3] Boedtkjer, Ebbe 0000-0002-5078-9279 [4]

Affiliations

  1. [1] University of Oxford
    2. [NORA names: United Kingdom; Europe, Non-EU; OECD];
  2. [2] Cell Death and Metabolism, Center for Autophagy, Recycling and Metabolism, Danish Cancer Institute, Copenhagen, Denmark.
    3. [NORA names: Denmark; Europe, EU; Nordic; OECD];
  3. [3] Moffitt Cancer Center
    4. [NORA names: United States; America, North; OECD];
  4. [4] Aarhus University
    5. [NORA names: AU Aarhus University; University; Denmark; Europe, EU; Nordic; OECD]

Abstract

Cancer metabolism produces large fluxes of lactate and H+, which are extruded by membrane transporters. However, H+ production and extrusion must be coupled by diffusion, facilitated by mobile buffers. Yan et al. propose that carnosine, generated by CARNS2, provides this mobile buffering and enables lysosomal functions that block T cell surveillance.

Keywords

T cell surveillance, buffer, cancer, cancer metabolism, carnosine, cell surveillance, diffusion, extrusion, flux, flux of lactate, function, lactate, lysosomal function, lysosomal release, membrane, membrane transport, metabolism, mobile buffers, production, surveillance, transport

Data Provider: Digital Science

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