Article, 2024

Type 2–polarized memory B cells hold allergen-specific IgE memory

Science Translational Medicine, ISSN 1946-6242, 1946-6234, Volume 16, 733, Page eadi0944, 10.1126/scitranslmed.adi0944

Contributors

Koenig, Joshua Frank Ernest 0000-0002-8909-5039 [1] Knudsen, Niels Peter Hell 0000-0003-1400-5657 [2] Phelps, Allyssa 0000-0002-5025-7459 [1] Bruton, Kelly M 0000-0003-0817-6134 [1] Hoof, Ilka 0000-0003-3827-7227 [2] Lund, Gitte 0000-0003-2221-7465 [2] Libera, Danielle Della [1] Lund, Anders 0000-0003-0051-8400 [2] Christensen, Lars Harder 0000-0003-4230-7820 [2] Glass, David Richard 0000-0001-9924-167X [3] Walker, Tina D [1] Fang, Allison [1] Waserman, Susan [1] Jordana, Manel [1] Andersen, Peter Sejer 0000-0003-3971-0467 [2]

Affiliations

  1. [1] McMaster University
    2. [NORA names: Canada; America, North; OECD];
  2. [2] ALK-Abelló (Denmark)
    3. [NORA names: ALK-Abello; Private Research; Denmark; Europe, EU; Nordic; OECD];
  3. [3] Fred Hutch Cancer Center
    4. [NORA names: United States; America, North; OECD]

Abstract

Allergen-specific immunoglobulin E (IgE) antibodies mediate pathology in diseases such as allergic rhinitis and food allergy. Memory B cells (MBCs) contribute to circulating IgE by regenerating IgE-producing plasma cells upon allergen encounter. Here, we report a population of type 2-polarized MBCs defined as CD23hi, IL-4Rαhi, and CD32low at both the transcriptional and surface protein levels. These MBC2s are enriched in IgG1- and IgG4-expressing cells while constitutively expressing germline transcripts for IgE. Allergen-specific B cells from patients with allergic rhinitis and food allergy were enriched in MBC2s. Furthermore, MBC2s generated allergen-specific IgE during sublingual immunotherapy, thereby identifying these cells as a major reservoir for IgE. The identification of MBC2s provides insights into the maintenance of IgE memory, which is detrimental in allergic diseases but could be beneficial in protection against venoms and helminths.

Keywords

B cells, IgE, IgE-producing plasma cells, IgE., IgG1, MBC2, allergen encounter, allergen-specific B cells, allergen-specific IgE, allergen-specific immunoglobulin E, allergens, allergic diseases, allergic rhinitis, allergy, antibodies, cells, circulating IgE, constitution, disease, encounters, food, food allergy, germline transcription, helminths, identification, immunoglobulin E, immunotherapy, levels, maintenance, memory, memory B cells, pathology, patients, plasma cells, population, protection, protein levels, reservoir, rhinitis, sublingual immunotherapy, surface, surface protein levels, transcription, type, venom

Funders

  • Cancer Research Institute

Data Provider: Digital Science

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