Article,
Left Atrial Appendage Occlusion and Post-procedural Antithrombotic Management
Contributors
Kramer, Anders Dahl
0000-0002-5546-8693
[1]
[2]
Patti, Giuseppe
0000-0002-5404-3968
[3]
[4]
Berti, Sergio
0000-0002-5244-0556
[5]
Korsholm, Kasper
0000-0003-4724-0880
(Corresponding author)
[1]
[2]
Affiliations
- [1] Aarhus University Hospital [NORA names: Central Denmark Region; Hospital; Denmark; Europe, EU; Nordic; OECD];
- [2] Department of Cardiology, Aarhus University Hospital, Palle Juul-Jensens Boulevard 99, 8200 Aarhus, Denmark;, anha@clin.au.dk, (A.K.);, je.nielsen.kudsk@gmail.com, (J.E.N.-K.)
- [3] Azienda Ospedaliero Universitaria Maggiore della Carita [NORA names: Italy; Europe, EU; OECD];
- [4] University of Eastern Piedmont Amadeo Avogadro [NORA names: Italy; Europe, EU; OECD];
- [5] Department of Interventional and Diagnostic Cardiology, Fondazione CNR-Regione Toscana G, Monasterio, Ospedale del Cuore, 54100 Massa, Italy;, sergio.berti@me.com [NORA names: Italy; Europe, EU; OECD]
Abstract
Left atrial appendage occlusion (LAAO) is an established alternative to oral anticoagulation for stroke prevention in atrial fibrillation. Antithrombotic therapy is used in the post-procedural period to prevent device-related thrombosis (DRT). The risk of DRT is considered highest in the first 45-90 days after device implantation, based on animal studies of the device healing process. Clinically applied antithrombotic regimens vary greatly across studies, continents, and centers. This article gives an overview of the evidence behind current antithrombotic regimens, ongoing randomized trials, and future post-procedural management.
Keywords
alternative,
alternative to oral anticoagulation,
animal studies,
animals,
anticoagulation,
antithrombotic regimens,
antithrombotic therapy,
appendage occlusion,
atrial fibrillation,
center,
continent,
days,
device implantation,
device-related thrombosis,
devices,
evidence,
fibrillation,
healing process,
implantation,
left atrial appendage occlusion,
management,
occlusion,
oral anticoagulants,
overview,
period,
post-procedural management,
post-procedure period,
prevention,
process,
randomized trials,
regimens,
risk,
stroke,
stroke prevention,
study,
therapy,
thrombosis,
trials
