open access publication

Preprint, 2024

SARS-CoV-2 infection in pregnancy in Denmark – characteristics and outcomes after confirmed infection in pregnancy: a nationwide, prospective, population-based cohort study

Authorea, 10.22541/au.170666114.47690574/v1

Contributors

Aabakke, Anna J M 0000-0003-4754-506X [1] Krebs, Lone 0000-0001-5433-4776 [2] Petersen, Tanja [3] Kjeldsen, Frank [3] Corn, Giulia [4] Wøjdemann, Karen Reinhold 0000-0002-6707-1677 [5] Ibsen, Mette [6] Jonsdottir, Fjola 0000-0001-5661-5379 [7] Rønneberg, Elisabeth Thal [7] Andersen, Charlotte [8] Sundtoft, Iben Blaabjerg 0000-0002-1602-2517 [9] Clausen, Tine [10] Milbak, Julie 0000-0002-4170-6558 [11] Burmester, Lars [12] Lindved, Birgitte Freilev [13] Thorsen-Meyer, Annette [14] Khalil, Mohammed [15] Henriksen, Birgitte [15] Jønsson, Lisbeth [16] Andersen, Lise Lotte Torvin 0000-0003-2997-2228 [3] Karlsen, Kamilla Kannegård [3] Pedersen, Monica [17] Klemmensen, Aase [18] Vestgaard, Marianne [18] Thisted, Dorthe Louise Ahrenkiel 0000-0002-0201-9552 [19] Tatla, Manrinder Kaur [19] Andersen, Line [20] Brülle, Anne-Line 0000-0002-8096-7347 [21] Gulbech, Arense Vinding [21] Andersson, Charlotte [22] Farlie, Richard N 0000-0001-5286-3244 [23] Hansen, Lea [24] Hvidman, Lone Egly 0000-0002-8006-6194 [24] Sørensen, Anne [22] Rathcke, Sidsel Linneberg 0000-0002-5408-2684 [22] Rubin, Katrine [25] Petersen, Lone [25] Joergensen, Jan Stener [3] Stokholm, Lonny [25] Bliddal, Mette 0000-0002-7637-3730 [25]

Affiliations

  1. [1] Copenhagen University Hospital - Holbæk
  2. [2] Amager and Hvidovre Hospital
    3. [NORA names: Capital Region of Denmark; Hospital; Denmark; Europe, EU; Nordic; OECD];
  3. [3] Odense University Hospital
    4. [NORA names: Region of Southern Denmark; Hospital; Denmark; Europe, EU; Nordic; OECD];
  4. [4] Statens Serum Institut Afdeling for Epidemiologisk Forskning
  5. [5] Bornholms Hospital
    6. [NORA names: Capital Region of Denmark; Hospital; Denmark; Europe, EU; Nordic; OECD];

Abstract

Objective To identify risk factors for and outcomes after SARS-CoV-2 infection and severe COVID-19 in pregnancy Design Prospective population-based cohort study Setting Denmark Population All pregnancies between 1 March and 31 October 2020 Methods Using data from the Danish National Patient Register and Danish Microbiology Database and prospectively registered data from medical records, we compared women with a positive SARS-CoV-2 test during pregnancy to non-infected pregnant women. Severe infection was defined as hospital admission due to COVID-19. Main Outcome Measures Pregnancy, delivery, maternal, and neonatal outcomes. Results Among 82,682 pregnancies, 418 women had SARS-CoV-2 infection during pregnancy, corresponding to an incidence of 5.1 per 1000 pregnancies, 23 (5.5%) of which required hospital admission due to COVID-19. Risk factors for infection were asthma (OR 2.19 [1.41–3.41]) and being foreign born (OR 2.12 [1.70–2.64]). Risk factors for hospital admission due to COVID-19 included obesity (OR 2.74 [1.00–7.51]), smoking (OR 4.69 [1.58–13.90]), infection after gestational age in weeks (GA) 22 (GA 22–27: OR 3.77 [1.16–12.29]; GA 28–36: OR 4.76 [1.60–14.12]) and having asthma (OR 4.53 [1.39–14.79]). We found no difference in any obstetric or neonatal outcomes. Conclusions Severe outcomes of SARS-CoV-2 infection in pregnancy are rare. Funding The Danish Ministry of Higher Education and Science (Reg. 0237-00007B) and The Region of Southern Denmark and Region Zealand’s shared fund for joint health research projects (Reg. A767) Keywords Severe acute respiratory syndrome coronavirus 2; COVID-19; Obstetric delivery; Pregnancy complications; Pregnancy outcome; Cohort studies; Prospective studies.

Keywords

COVID-19, Danish, Danish Microbiology Database, Danish Ministry, Denmark, Denmark's population, GA, Ministry, Nationwide, Region Zealand, Region of Southern Denmark, SARS-CoV-2, SARS-CoV-2 infection, SARS-CoV-2 testing, Southern Denmark, Zealand, acute respiratory syndrome coronavirus 2, admission, age, asthma, characteristics, cohort, cohort study, complications, coronavirus 2, data, database, delivery, factors, funding, gestational age, health research projects, hospital, hospital admission, incidence, infection, keywords, medical records, microbiology database, neonatal outcomes, non-infected pregnant women, obesity, obstetric delivery, outcome of SARS-CoV-2 infection, outcomes, population, population-based cohort study, positive SARS-CoV-2 test, pregnancy, pregnancy complications, pregnancy outcomes, pregnant women, project, prospective study, records, region, research project, respiratory syndrome coronavirus 2, results, risk, risk factors, severe COVID-19, severe acute respiratory syndrome coronavirus 2, severe infections, severe outcomes, severe outcomes of SARS-CoV-2 infection, smoking, study, syndrome coronavirus 2, test, weeks, women

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