Chapter, 2024

Chapter 8 Type VIII collagen

Biochemistry of Collagens, Laminins and Elastin 9780443156175, Pages 81-88

Editors:

Publisher: Elsevier

DOI: 10.1016/b978-0-443-15617-5.00044-5

Contributors

Alexdóttir, Marta Sorokina 0000-0002-7028-4307 [1] Breisnes, Helene Wallem 0009-0004-8400-2237 [1] Hansen, Niels Ulrik Brandt [1] Gudmann, Natasja Staehr 0000-0001-6892-7177 [1] Willumsen, Nicholas 0000-0002-5207-5173 [1] Karsdal, Morten Asser 0000-0002-4764-5100 [1]

Affiliations

  1. [1] Nordic Bioscience (Denmark)
    2. [NORA names: Nordic Bioscience; Private Research; Denmark; Europe, EU; Nordic; OECD]

Abstract

Type VIII collagen is a short-chain, nonfibrillar collagen and the major component of Descemet's membrane. It is mainly synthesized by endothelial cells and can be found in the heart, brain, liver, lung, muscles, and cartilage, where it forms unique hexagonal lattice structures. Type VIII collagen is also present around actively proliferating vessels of brain tumors and in large fibrotic vessels of angiomas. Mutations are involved in Fuchs's endothelial dystrophy. Type VIII collagen has structural and signaling properties. The signaling properties originate from the noncollagenous C-terminal globular NC1 (aa 572–744) known as vastatin, an endogenous antiangiogenic polypeptide. C8–C is a serological marker for the C-terminal of type VIII collagen. Elevated levels of C8–C have been measured in chronic obstructive lung disease, angina pectoris, systemic sclerosis, and certain cancers compared to healthy individuals.

Keywords

C-terminal, C8-C, Descemet, Descemet's membrane, Fuchs, Fuchs endothelial dystrophy, NC1, VIII collagen, angina pectoris, angioma, antiangiogenic polypeptide, brain, brain tumors, cancer, cartilage, cells, chronic obstructive lung disease, collagen, disease, dystrophy, elevated levels, endothelial cells, endothelial dystrophy, fibrotic vessels, healthy individuals, heart, hexagonal lattice structure, individuals, lattice structure, levels, liver, lung, lung disease, markers, membrane, muscle, mutations, nonfibrillar collagens, obstructive lung disease, pectoris, polypeptide, proliferating vessels, properties, sclerosis, serological markers, short chains, signal, signaling properties, structure, systemic sclerosis, tumor, type, type VIII collagen, unique hexagonal lattice structure, vastatins

Data Provider: Digital Science

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