Chapter, 2024

Chapter 23 Type XXIII collagen

Biochemistry of Collagens, Laminins and Elastin 9780443156175, Pages 199-202

Editors:

Publisher: Elsevier

DOI: 10.1016/b978-0-443-15617-5.00009-3

Contributors

Crespo-Bravo, Marina [1] Kehlet, Stephanie Nina [1] Jessen, Henrik 0000-0003-4985-1132 [1] Karsdal, Morten Asser 0000-0002-4764-5100 [1]

Affiliations

  1. [1] Nordic Bioscience (Denmark)
    2. [NORA names: Nordic Bioscience; Private Research; Denmark; Europe, EU; Nordic; OECD]

Abstract

Type XXIII collagen is a type II transmembrane collagen found in healthy human and mouse tissues of the lung, cornea, skin, tendon, amnion, and to a lesser extent in the kidney and placenta. Currently, its function is unknown; however, type XXIII collagen is a component of many epithelia and expressed on epithelial cell surfaces, suggesting a role in the formation or maintenance of cell-cell contacts or the polarization of epithelial cells. Type XXIII collagen levels in patient samples have been proposed as a new biomarker of prostate cancer progression and recurrence. Type XXIII collagen has been detected in urine samples of prostate cancer and non-small-cell lung cancer patients and can discriminate between controls and cancer patients, indicating a potential role as a new diagnostic tool in certain types of cancer. There are currently no mutations in humans or mice associated with biological functions; no biomarkers have been put forward.

Keywords

amnion, biological functions, biomarkers, cancer, cancer patients, cancer progression, cell surface, cell-cell contact, cells, collagen, collagen levels, components, contact, control, cornea, diagnostic tool, epithelia, epithelial cell surface, epithelial cells, extent, formation, function, humans, kidney, lesser extent, levels, lung, lung cancer patients, maintenance, maintenance of cell-cell contacts, mice, mouse tissues, mutations, non-small-cell lung cancer patients, patient samples, patients, placenta, polarity of epithelial cells, polarization, progression, prostate cancer, prostate cancer progression, recurrence, samples, samples of prostate cancer, skin, surface, tendon, tissue, tools, transmembrane collagen, type, urine, urine samples

Data Provider: Digital Science

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