Chapter, 2024

Chapter 39 Use of extracellular matrix biomarkers in clinical research

Biochemistry of Collagens, Laminins and Elastin 9780443156175, Pages 435-443

Editors:

Publisher: Elsevier

DOI: 10.1016/b978-0-443-15617-5.00032-9

Contributors

Bihlet, Asger Reinstrup 0000-0002-6944-1731 [1] Thudium, Christian Schneider [1] Bager, Cecilie Liv 0000-0003-2430-9777 [1] Karsdal, Morten Asser 0000-0002-4764-5100 [1]

Affiliations

  1. [1] Nordic Bioscience (Denmark)
    2. [NORA names: Nordic Bioscience; Private Research; Denmark; Europe, EU; Nordic; OECD]

Abstract

In pathological conditions involving alterations in the activity of extracellular matrix (ECM)-targeted proteases, the product of protease activity on the surrounding tissue yields ECM fragments specific for the pathological process. Fragments of ECM components are suitable for use as biomarkers in several disease areas characterized by abnormal ECM turnover. In bone diseases, early changes in fragments of cross-linked collagen type I (CTX-I) are a standard surrogate marker of clinical benefit, while other ECM markers are being investigated as diagnostic, predictive, and prognostic markers in other disease areas; they are particularly promising in respiratory, hepatic, and arthritic conditions. ECM biomarkers can also be used to monitor tissue turnover in translational research of potential drug candidates using ex vivo tissue explants.

Keywords

CTX-I, ECM, ECM components, ECM fragments, ECM markers, ECM turnover, abnormal ECM turnover, activity, alterations, area, arthritic conditions, benefits, biomarkers, bone, bone disease, candidates, changes, chapter, clinical benefit, clinical research, collagen type I, components, conditions, cross-linked collagen type I, disease, disease areas, drug candidates, ex vivo tissue explants, explants, extracellular matrix biomarkers, fragments, fragments of ECM components, marker of clinical benefit, markers, matrix biomarkers, pathological conditions, pathological processes, potential drug candidates, process, production, production of protease activity, prognostic marker, protease, protease activity, research, surrogate marker, tissue explants, tissue turnover, translational research, turnover, type I

Data Provider: Digital Science

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