Chapter, 2024

Chapter 38 The roles of collagens and fibroblasts in cancer

Biochemistry of Collagens, Laminins and Elastin 9780443156175, Pages 419-434

Editors:

Publisher: Elsevier

DOI: 10.1016/b978-0-443-15617-5.00029-9

Contributors

Nissen, Neel Ingemann 0000-0002-8970-8798 [1] Karsdal, Morten Asser 0000-0002-4764-5100 [1] Cox, Thomas Robert 0000-0001-9294-1745 [2] [3] Willumsen, Nicholas 0000-0002-5207-5173 [1]

Affiliations

  1. [1] Nordic Bioscience (Denmark)
    2. [NORA names: Nordic Bioscience; Private Research; Denmark; Europe, EU; Nordic; OECD];
  2. [2] The Kinghorn Cancer Centre
    3. [NORA names: Australia; Oceania; OECD];
  3. [3] UNSW Sydney
    4. [NORA names: Australia; Oceania; OECD]

Abstract

A hallmark of cancerous and fibrotic diseases is disruption of tissue microarchitecture and associated organ fibrosis or tumor fibrosis (desmoplasia). The fibrotic response is characterized by excessive turnover, deposition, post-translational modification, and architectural remodeling of the extracellular matrix driven primarily by altered fibroblast activity, chronic inflammation, and angiogenesis. This typically leads to increased collagen production and cross-linking and altered degradation of the collagenous matrix. This results in the loss of correct tissue organization and aberrant cellular behavior, release of matrix-bound growth factors, and unmasking of cryptic sites on collagens with potent signaling activity. All these collagen alterations drive disease progression and can affect treatment response. Tools to detect these remodeling events could be used as biomarkers of a specific fibrotic, angiogenic, or inflammatory signature. Here, we introduce some of the important roles that collagens and collagen remodeling play in cancer and touch on potential biomarkers for use in the clinic.

Keywords

aberrant cellular behavior, activity, alterations, angiogenesis, architectural remodeling, behavior, biomarkers, cancer, cellular behavior, chronic inflammation, clinic, collagen, collagen alterations, collagen matrix, collagen production, cross-linking, cryptic sites, degradation, deposition, desmoplasia, disease, disease progression, disruption, events, excessive turnover, extracellular matrix, factors, fibroblast activation, fibroblasts, fibrosis, fibrotic diseases, fibrotic response, growth factor, increased collagen production, inflammation, inflammatory signature, loss, matrix, matrix-bound growth factors, microarchitecture, modification, organ fibrosis, organization, play, post-translational modifications, potential biomarkers, production, progression, remodeling, remodeling events, response, results, signal, signaling activity, signature, sites, tissue microarchitecture, tissue organization, tools, touch, treatment, treatment response, tumor, tumor fibrosis, turnover, unmasking

Data Provider: Digital Science

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