Article,
Harnessing neoantigen-specific T cells for precision cancer immunotherapy
Affiliations
- [1] Copenhagen University Hospital [NORA names: Capital Region of Denmark; Hospital; Denmark; Europe, EU; Nordic; OECD]
Abstract
Several novel personalized therapies focus on targeting neoantigens. Such strategies require the identification of suitable vaccine neoepitopes or neoantigen-specific T cell receptor (TCR) clonotypes. Herein, we discuss a recently published report that describes a combined transcriptional and phenotype signature, NeoTCRPBL, that enables the minimally invasive identification of rare neoantigen-specific TCRs from peripheral blood that might enable more-effective T cell-based therapies against cancer.
Keywords
T cell receptor,
T cell-based therapies,
T cells,
blood,
cancer,
cancer immunotherapy,
clonotypes,
identification,
immunotherapy,
minimally invasive identification,
minimization,
neoantigen-specific T cell receptors,
neoantigen-specific T cells,
neoantigens,
neoepitopes,
peripheral blood,
personalized therapy,
phenotype,
phenotypic signatures,
precision,
precision cancer immunotherapy,
published reports,
receptors,
reports,
signature,
strategies,
targeting neoantigens,
therapy,
vaccine