Chapter, 2024

Chapter 24 Type XXIV collagen

Biochemistry of Collagens, Laminins and Elastin 9780443156175, Pages 203-205

Editors:

Publisher: Elsevier

DOI: 10.1016/b978-0-443-15617-5.00006-8

Contributors

Nielsen, Signe Holm 0000-0002-4612-1014 [1] Crespo-Bravo, Marina [1] [2] Karsdal, Morten Asser 0000-0002-4764-5100 [1]

Affiliations

  1. [1] Nordic Bioscience (Denmark)
    2. [NORA names: Nordic Bioscience; Private Research; Denmark; Europe, EU; Nordic; OECD];
  2. [2] University of Copenhagen
    3. [NORA names: KU University of Copenhagen; University; Denmark; Europe, EU; Nordic; OECD]

Abstract

Type XXIV collagen is a fibrillar collagen containing two collagenous domains and three noncollagenous domains. The amino-terminal peptide contains a thrombospodin-N-terminal-like motif and a highly charged segment interspersed with several tyrosine residues. Type XXIV collagen is predominately expressed in the formation of bone but to a lesser extent is also found in soft tissues such as the brain, muscle, kidneys, spleen, liver, lung, testis, and ovary. The gene COL24A1 is increased during squamous cell carcinoma of the head and neck could be a marker of osteoblast differentiation and certain types of cancers. Currently, there are no mutations in humans or mice associated with biological functions, and no biomarkers have been put forward.

Keywords

COL24A1, amino-terminal peptide, biological functions, biomarkers, bone, brain, cancer, carcinoma, cell carcinoma, charged segments, collagen, collagenous domain, differentiation, domain, extent, fibrillar collagen, formation, formation of bone, function, genes, head, head and neck, humans, kidney, lesser extent, liver, lung, marker of osteoblast differentiation, markers, mice, motif, muscle, mutations, neck, noncollagenous domain, osteoblast differentiation, ovary, peptide, residues, segments, soft tissue, spleen, squamous cell carcinoma, testis, tissue, type, tyrosine, tyrosine residues

Data Provider: Digital Science

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