Chapter, 2024

Chapter 26 Type XXVI collagen

Biochemistry of Collagens, Laminins and Elastin 9780443156175, Pages 213-216

Editors:

Publisher: Elsevier

DOI: 10.1016/b978-0-443-15617-5.00014-7

Contributors

Manon-Jensen, Tina [1] Guiliani, A.E.M [1] Karsdal, Morten Asser 0000-0002-4764-5100 [1]

Affiliations

  1. [1] Nordic Bioscience (Denmark)
    2. [NORA names: Nordic Bioscience; Private Research; Denmark; Europe, EU; Nordic; OECD]

Abstract

Type XXVI collagen contains collagenous domains in its structure but does not fit squarely within any of the collagen family subgroups. Trimers of collagen type XXVI are formed from the intermolecular disulfide bonds between NC1 regions. This trimerization formation distinguishes type XXVI collagen from fibrillar collagens, where trimer formation is associated with the C-propeptide region. Type XXVI collagen is specifically expressed in adult testis and ovary tissues. The highest levels are found in the reproductive tissues of neonates. Consequently, type XXVI collagen has been suggested to be associated with the generation and modeling of tissues. Research on type XXVI collagen is only now emerging, and no biomarkers or mutations associated with this protein have been discovered.

Keywords

C-propeptide, C-propeptide region, NC1, XXVI, adult testis, biomarkers, bonds, collagen, collagenous domain, disulfide bonds, domain, family subgroups, fibrillar collagen, formation, generation, higher levels, intermolecular disulfide bonds, levels, model, model of tissue, mutations, neonates, ovary tissues, protein, region, reproductive tissues, research, structure, subgroups, testis, tissue, tissues of neonates, trimer, trimer formation, type

Data Provider: Digital Science

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