Chapter,
Chapter 26 Type XXVI collagen
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Editors:
DOI:
Affiliations
- [1] Nordic Bioscience (Denmark) [NORA names: Nordic Bioscience; Private Research; Denmark; Europe, EU; Nordic; OECD]
Abstract
Type XXVI collagen contains collagenous domains in its structure but does not fit squarely within any of the collagen family subgroups. Trimers of collagen type XXVI are formed from the intermolecular disulfide bonds between NC1 regions. This trimerization formation distinguishes type XXVI collagen from fibrillar collagens, where trimer formation is associated with the C-propeptide region. Type XXVI collagen is specifically expressed in adult testis and ovary tissues. The highest levels are found in the reproductive tissues of neonates. Consequently, type XXVI collagen has been suggested to be associated with the generation and modeling of tissues. Research on type XXVI collagen is only now emerging, and no biomarkers or mutations associated with this protein have been discovered.