Chapter, 2024

Chapter 41 Extracellular matrix and endotypes

Biochemistry of Collagens, Laminins and Elastin 9780443156175, Pages 455-458

Editors:

Publisher: Elsevier

DOI: 10.1016/b978-0-443-15617-5.00030-5

Contributors

Hannani, Monica T 0000-0002-4123-6832 [1] Bay-Jensen, Anne-Christine Bay 0000-0001-7952-9297 [1] Karsdal, Morten Asser 0000-0002-4764-5100 [1] Thudium, Christian Schneider [1]

Affiliations

  1. [1] Nordic Bioscience (Denmark)
    2. [NORA names: Nordic Bioscience; Private Research; Denmark; Europe, EU; Nordic; OECD]

Abstract

The extracellular matrix (EMC) is a pivotal regulator of cell and tissue behavior and plays a central role in tissue homeostasis as well as in organ pathologies and system diseases. The extracellular matrix can under pathological conditions alter the remodeling of cell types and have profound effects on cellular and clinical phenotypes. Aberrant ECM remodeling can result in elevated levels of tissue degradation and formation products, yielding unique protein fingerprints reflective of phenotypic changes to cell and tissue. These can reveal distinct disease phenotypes and, potentially, clinically actionable molecular endotypes. With the evolving concept of personalized medicine, there is an increasing demand for improved endotyping of patients to better delineate the underlying molecular causes of a disease and allow for more targeted treatments. This chapter highlights the importance of the ECM in the context of disease and the clinical applicability of ECM-related molecular endotypes.

Keywords

ECM, ECM remodeling, EMC, aberrant ECM remodeling, applications, behavior, cause, cell types, cells, changes to cells, clinic, clinical application, clinical phenotype, concept of personalized medicine, conditions, context, context of disease, degradation, demand, disease, disease phenotype, elevated levels, endotypes, endotyping of patients, evolving concept, extracellular matrix, fingerprint, formate production, formation, homeostasis, increasing demand, level of tissue degradation, matrix, medicine, molecular causes, molecular endotypes, organic pathology, organization, pathological conditions, pathology, patients, personalized medicine, phenotype, production, protein, protein fingerprints, regulation, regulation of cells, remodeling, system, systemic disease, targeted treatment, tissue, tissue behavior, tissue degradation, tissue homeostasis, treatment, type

Data Provider: Digital Science

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