Chapter, 2024

Chapter 3 Type III collagen

Biochemistry of Collagens, Laminins and Elastin 9780443156175, Pages 23-35

Editors:

Publisher: Elsevier

DOI: 10.1016/b978-0-443-15617-5.00031-7

Contributors

Lønsmann, Ida [1] Pehrsson, Martin 0000-0002-4787-5563 [1] Nielsen, Mette Juul Fisker 0000-0002-4448-8955 [1] Villesen, Ida Falk 0000-0001-7921-9707 [1] Sinkeviciute, Dovile 0000-0003-4275-388X [1] Bay-Jensen, Anne-Christine Bay 0000-0001-7952-9297 [1] Karsdal, Morten Asser 0000-0002-4764-5100 [1]

Affiliations

  1. [1] Nordic Bioscience (Denmark)
    2. [NORA names: Nordic Bioscience; Private Research; Denmark; Europe, EU; Nordic; OECD]

Abstract

Type III collagen is a fibrillar collagen of homotrimers containing α1(III) chains supercoiled around one another in a right-handed triple helix. Type III collagen is secreted by fibroblasts and other mesenchymal cell types, making it a major player in various inflammation-associated pathologies, such as lung injury, arthropathies, liver diseases, kidney fibrosis, hernia, and vascular disorders. Type III collagen and type I collagen are the main constituents of the interstitial matrix. Type III collagen mutations have been associated with Ehlers–Danlos syndrome, vascular deficiency, and aortic and arterial aneurysms. Several biomarkers for type III collagen formation and degradation have been developed and used extensively as investigatory tools in drug development and health care. In particular, the identification of biomarkers measuring the N-terminal propeptide of type III collagen as a marker of formation has proven valuable as a tool for monitoring liver fibrosis.

Keywords

A1(III, Ehlers-Danlos syndrome, I collagen, III collagen, N-terminal propeptide, N-terminal propeptide of type III collagen, aneurysm, artery aneurysm, arthropathy, associated with Ehlers-Danlos syndrome, biomarkers, care, cell types, chain, collagen, collagen formation, collagen mutations, constituents, deficiency, degradation, development, disease, disorders, drug, drug development, fibrillar collagen, fibroblasts, fibrosis, formation, health, health care, hernia, homotrimer, identification, identification of biomarkers, inflammation-associated pathologies, injury, interstitial matrix, investigatory tool, kidney, kidney fibrosis, liver, liver disease, liver fibrosis, lung, lung injury, markers, markers of formation, matrix, mesenchymal cell types, monitoring liver fibrosis, mutations, pathology, syndrome, tools, type, type I collagen, type III collagen, type III collagen formation, vascular deficiency, vascular disorders

Data Provider: Digital Science

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