Chapter,
Chapter 10 Type X collagen
,
Editors:
DOI:
Contributors
Gudmann, Natasja Staehr
0000-0001-6892-7177
[1]
Willumsen, Nicholas
0000-0002-5207-5173
[1]
Karsdal, Morten Asser
0000-0002-4764-5100
[1]
Bay-Jensen, Anne-Christine Bay
0000-0001-7952-9297
[1]
Affiliations
- [1] Nordic Bioscience (Denmark) [NORA names: Nordic Bioscience; Private Research; Denmark; Europe, EU; Nordic; OECD]
Abstract
Type X collagen is a network-forming collagen that is mainly expressed in hypertrophic chondrocytes in cartilage of the hypertrophic zone of the growth plate, in the calcified zone of articular cartilage of long bones, where type X collagen seems to facilitate calcification, and in human lumbar intervertebral discs. The most common genetic disorder is Schmid metaphyseal chondrodysplasia. Biomarkers of type X collagen are only now emerging and have been shown to be elevated in rheumatological disorders affecting bone and cartilage and in cancer.
Keywords
Schmid,
Schmid metaphyseal chondrodysplasia,
X collagen,
biomarkers,
bone,
calcification,
calcified zone,
cancer,
cartilage,
chondrocytes,
chondrodysplasia,
collagen,
disk,
disorders,
disorders affecting bone,
genetic disorders,
growth,
growth plate,
human lumbar intervertebral discs,
hypertrophic chondrocytes,
hypertrophic zone,
intervertebral disc,
long bones,
lumbar intervertebral discs,
metaphyseal chondrodysplasia,
plate,
type,
type X collagen,
zone
