Chapter, 2024

Diabetic Retinopathy

Textbook of Diabetes 9781119697473, Pages 629-639

Editors: Richard I.G. Holt; Allan Flyvbjerg

Publisher: Wiley

DOI: 10.1002/9781119697473.ch43

Contributors

Bek, Toke 0000-0002-0409-2534 [1] [2]

Affiliations

  1. [1] Aarhus University
  2. [NORA names: AU Aarhus University; University; Denmark; Europe, EU; Nordic; OECD];
  3. [2] Aarhus University Hospital
  4. [NORA names: Central Denmark Region; Hospital; Denmark; Europe, EU; Nordic; OECD]

Abstract

The diabetesā€related complication developing in the retina, diabetic retinopathy, is a potentially much more serious condition and constitutes one of the most frequent causes of blindness worldwide. Proliferative diabetic retinopathy is initiated by occlusion of capillaries in the retinal periphery. The consequent ischaemia and hypoxia stimulate the release of growth factors that stimulate the formation of neovascularizations proximally from the ischaemic areas. Proliferative diabetic retinopathy is initiated by occlusion of capillaries in the retinal periphery. The consequent ischaemia and hypoxia stimulate the release of growth factors that stimulate the formation of neovascularizations proximally from the ischaemic areas. The initial morphological changes in diabetic retinopathy are red dots in the macular area representing capillary microaneurysms or dot haemorrhages. The progression of early diabetic retinopathy may result in the development of retinal oedema and/or exudates representing precipitations of plasma proteins, predominantly in the macular area.

Keywords

area, blindness, capillaries, capillary microaneurysms, cause, changes, complications, conditions, development, development of retinal edema, diabetes-related complications, diabetic retinopathy, dot haemorrhages, dots, edema, exudates, factors, formation, formation of neovascularization, frequent cause, growth factor, haemorrhage, hypoxia, ischaemia, ischaemic area, macular, macular area, microaneurysms, morphological changes, neovascularization, occlusion, occlusion of capillaries, periphery, plasma proteins, precipitation, precipitation of plasma proteins, progression, proliferative diabetic retinopathy, protein, red dots, release, release of growth factors, retina, retinal edema, retinal periphery, retinopathy

Data Provider: Digital Science