Article, 2023

The cortical thickness of tricenarian cocaine users assembles features of an octogenarian brain

Journal of Neuroscience Research, ISSN 0360-4012, 1097-4547, Volume 102, 1, Page e25287, 10.1002/jnr.25287

Contributors

Rothmann, Leonardo Melo 0000-0001-5988-2368 [1] [2] Tondo, Lucca Pizzato 0000-0002-0086-4875 [2] Borelli, Wyllians Vendramini 0000-0001-9282-0601 [2] Esper, Nathalia Bianchini 0000-0003-3218-9226 [3] Portolan, Eduardo Tavares [2] Franco, Alexandre Rosa 0000-0002-1552-1090 [3] [4] [5] Portuguez, Mirna Wetters 0000-0003-4068-6249 [2] Ferreira, Pedro Eugenio Mazzucchi Santana [2] Bittencourt, Augusto Martins Lucas 0000-0002-6548-8882 [2] Soder, Ricardo Bernardi [2] Viola, Thiago Wendt 0000-0001-5446-1695 [2] Da Costa, Jaderson Costa 0000-0001-6776-1515 [2] Grassi-Oliveira, Rodrigo 0000-0001-9911-5921 (Corresponding author) [1] [2]

Affiliations

  1. [1] Aarhus University
    2. [NORA names: AU Aarhus University; University; Denmark; Europe, EU; Nordic; OECD];
  2. [2] Pontifical Catholic University of Rio Grande do Sul
    3. [NORA names: Brazil; America, South];
  3. [3] Child Mind Institute
    4. [NORA names: United States; America, North; OECD];
  4. [4] Nathan Kline Institute for Psychiatric Research
    5. [NORA names: United States; America, North; OECD];
  5. [5] New York University
    6. [NORA names: United States; America, North; OECD]

Abstract

It has been suggested that substance use disorders could lead to accelerated biological aging, but only a few neuroimaging studies have investigated this hypothesis so far. In this cross-sectional study, structural neuroimaging was performed to measure cortical thickness (CT) in tricenarian adults with cocaine use disorder (CUD, n1  = 30) and their age-paired controls (YC, n1  = 30), and compare it with octogenarian elder controls (EC, n1  = 20). We found that CT in the right fusiform gyrus was similar between CUD and EC, thinner than the expected values of YC. We also found that regarding CT of the right inferior temporal gyrus, right inferior parietal cortex, and left superior parietal cortex, the CUD group exhibited parameters that fell in between EC and YC groups. Finally, CT of the right pars triangularis bordering with orbitofrontal gyrus, right superior temporal gyrus, and right precentral gyrus were reduced in CUD when contrasted with YC, but those areas were unrelated to CT of EC. Despite the 50-year age gap between our age groups, CT of tricenarian cocaine users assembles features of an octogenarian brain, reinforcing the accelerated aging hypothesis in CUD.

Keywords

CUD, CuD group, EC, YC, YC group, accelerated aging hypothesis, accelerated biological aging, adults, age, age gap, age groups, age-paired controls, aging hypothesis, area, assembly features, biological age, brain, cocaine, cocaine use disorder, cocaine users, control, cortex, cortical thickness, cross-sectional study, disorders, elder controls, features, fusiform gyrus, gap, group, gyrus, hypothesis, inferior parietal cortex, inferior temporal gyrus, left superior parietal cortex, measure cortical thickness, neuroimaging, neuroimaging studies, orbitofrontal gyrus, parameters, parietal cortex, precentral gyrus, right fusiform gyrus, right inferior parietal cortex, right inferior temporal gyrus, right pars triangularis, right precentral gyrus, right superior temporal gyrus, rights, structural neuroimaging, study, substance use disorders, substances, superior parietal cortex, superior temporal gyrus, temporal gyrus, thickness, triangularis, use disorder, users, values

Funders

  • National Institute on Drug Abuse
  • National Council for Scientific and Technological Development
  • Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul

Data Provider: Digital Science

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