Article, 2024

Antibacterial and antioxidant wound dressings with pH responsive release properties accelerate chronic wound healing

Materials Today Physics, ISSN 2542-5293, Volume 40, Page 101316, 10.1016/j.mtphys.2023.101316

Contributors

Cao, Wuxiu [1] Xia, Dan 0000-0001-7892-7381 (Corresponding author) [1] Zhou, Linxi [1] Liu, Yuan [1] Wang, Donghui 0000-0002-1198-0978 (Corresponding author) [1] Liang, Chun Yong 0000-0003-4459-7470 [1] Chen, Menglin 0000-0002-2721-651X (Corresponding author) [2]

Affiliations

  1. [1] Hebei University of Technology
    2. [NORA names: China; Asia, East];
  2. [2] Aarhus University
    3. [NORA names: AU Aarhus University; University; Denmark; Europe, EU; Nordic; OECD]

Abstract

Accelerating chronic wound healing is of great clinical significance. In this study, a bilayer pad (PCL-TH/PVA-Alg@CUR) with tetracycline hydrochloride (TH) loaded polycaprolactone (PCL) nanofiber as the outer layer (PCL-TH), and poly (vinyl alcohol) (PVA) hydrogel loaded with sodium alginate microspheres (Alg) encapsulating of curcumin (CUR) as the inner layer (PVA-Alg@CUR) was prepared to accelerate the chronic wound healing. The prepared bilayer pad shows a porous structure and can release CUR specifically according to the pH of chronic wounds. Moreover, it has good water vapor transmittance and water absorption ability, and its mechanical properties can meet the daily expansion and contraction of the skin. The antimicrobial and antioxidant properties of the bilayer pads were verified by the inhibition zone, co-culture method and in vitro free radical scavenging experiments. In addition, in vivo experiments have shown that the bilayer pad can inhibit the bacteria at the wound site and accelerate the healing of the chronic diabetic wound infected by bacteria. This study indicates the prepared antibacterial and antioxidant bilayer dressing with pH responsive release property have potential clinical applications.

Keywords

Alg, ability, absorption ability, accelerating chronic wound healing, alcohol, alginate microspheres, antioxidant properties, applications, bacteria, bilayer, bilayer dressing, chronic diabetic wounds, chronic wound healing, chronic wounds, clinical application, clinical significance, co-culture, co-culture method, contraction, curcumin, daily expansion, diabetic wounds, dressing, encapsulation, encapsulation of curcumin, expansion, experiments, free radical scavenging experiments, healing, hydrochloride, hydrogels, in vivo experiments, inhibition, inhibition zone, inner layer, layer, mechanical properties, method, microspheres, nanofibers, outer layer, pH-responsive release properties, pad, poly, poly (vinyl alcohol, polycaprolactone, porous structure, properties, radical scavenging experiments, release properties, released CUR, scavenging experiments, significance, sites, skin, sodium, sodium alginate microspheres, structure, study, tetracycline, tetracycline hydrochloride, transmitter, vinyl alcohol, water, water absorption ability, water vapor transmittance, wound, wound dressing, wound healing, wound site, zone

Funders

  • National Natural Science Foundation of China

Data Provider: Digital Science

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