open access publication

Article, 2024

Electrosprayed Poly-butyl-succinate microparticles for sustained release of Ciprofloxacin as an antimicrobial delivery system

Powder Technology, ISSN 0032-5910, 1873-328X, Volume 432, Page 119152, 10.1016/j.powtec.2023.119152

Contributors

Puleo, Giorgia 0000-0002-1828-0157 [1] [2] Terracina, Francesca 0000-0002-4066-6638 [2] Catania, Valentina 0000-0002-9439-0980 [2] Scirè, Sergio [2] Schillaci, Domenico 0000-0003-2416-0474 [2] Licciardi, Mariano 0000-0003-4539-9337 (Corresponding author) [2]

Affiliations

  1. [1] University of Copenhagen
    2. [NORA names: KU University of Copenhagen; University; Denmark; Europe, EU; Nordic; OECD];
  2. [2] University of Palermo
    3. [NORA names: Italy; Europe, EU; OECD]

Abstract

The increasingly complex treatment of bacterial infections, and its relevance in the clinical setting, requires the development of innovative strategies to improve patients' quality of life. In this context, polymeric microparticles represents a versatile drug delivery system (DDS) capable of improving the antibiotics' efficacy in the treatments, by loading drugs while modifying their release profile. In this study we aimed to produce polymeric microparticles by electrospraying using Poly-Butyl-Succinate (PBS), a biodegradable and biocompatible polyester. This versatile and easy-to-use technique enabled the incorporation of the poorly water-soluble Ciprofloxacin (CPX) into the polymer matrix. CPX is a fluoroquinolone antibiotic, inhibiting bacterial replication and effectively treating various infections. PBS is a well-known water-insoluble polymer with tuneable chemical-physical properties, also used for tissue regeneration and wound healing applications. An ex-vivo permeation study on porcine skin, serving as a model for human skin, was performed to assess potential enhancement in drug permeation. The microparticles were characterized by means of different techniques (SEM-EDX, XRD, ATR-FTIR, DSC), and their degradation rate was tested in DPBS and human plasma. Moreover, the as-produced DDS enabled the sustained release of CPX for several days, which proved effective against S. aureus and P. aeruginosa and also against a reference group of bacteria of skin microbiota often involved in pathological processes that make wounds chronic and difficult to heal. MIC and MBC assays were conducted using different culture media. Effective antibacterial activity was observed, along with inhibition of P. aeruginosa biofilm formation at sub-MIC concentrations.

Keywords

DPBS, MBC, MBC assays, MIC, P. aeruginosa, S. aureus, activity, antibacterial activity, antibiotic efficacy, antibiotics, antimicrobial delivery systems, applications, assay, bacterial infections, bacterial replication, biocompatible polyesters, biofilm formation, chemical-physical properties, ciprofloxacin, clinical setting, complex treatment, concentration, context, culture, culture medium, days, degradation, degradation rate, delivery system, development, drug, drug delivery systems, drug permeation, effective antibacterial activity, efficacy, electrospray, enhancement, ex vivo permeation studies, formation, healing applications, human plasma, human skin, improve patient quality, improve patients' quality of life, incorporation, infection, inhibited bacterial replication, inhibition, inhibition of P. aeruginosa biofilm formation, life, loaded drug, matrix, medium, microbiota, microparticles, model, pathological processes, patients' quality of life, permeation, permeation studies, plasma, polyester, polymer, polymer matrix, polymeric microparticles, porcine, porcine skin, potential enhancement, process, profile, properties, quality of life, rate, reference, reference group, regeneration, releae of ciprofloxacine, release, release of ciprofloxacin, release profile, relevance, replication, sets, skin, skin microbiota, study, sub-MIC, sub-MIC concentrations, sustained release, sustained release of CIP, sustained release of ciprofloxacin, system, technique, tissue, tissue regeneration, treat various infections, treatment, treatment of bacterial infections, water-insoluble polymer, wound, wound healing applications

Data Provider: Digital Science

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