Article,
Effect of in utero and lactational exposure to a thyroid hormone system disrupting chemical on mouse metabolome and brain transcriptome
Contributors
Poulsen, Rikke
0000-0003-0475-9834
(Corresponding author)
[1]
Zekri, Yanis
0000-0003-4925-4610
[2]
Guyot, Romain
0000-0002-0029-6222
[2]
Flamant, F Rédéric
0000-0002-3360-2345
[2]
Hansen, Martin Nørregaard
0000-0002-4663-8742
[1]
Affiliations
- [1] Aarhus University [NORA names: AU Aarhus University; University; Denmark; Europe, EU; Nordic; OECD];
- [2] Institut de Génomique Fonctionnelle de Lyon [NORA names: France; Europe, EU; OECD]
Abstract
Mice were exposed to a low dose of the model thyroid hormone disruptor, propylthiouracil. Although this had only a modest effect on maternal thyroid hormones production, postnatal analysis of the pups' plasma by mass spectrometry and the brain striatum by RNA sequencing gave evidence of low lasting changes that could reflect an adverse effect on neurodevelopment. Overall, these methods proved to be sensitive enough to detect minor disruptions of thyroid hormone signalling in vivo.
Keywords
RNA,
RNA sequencing,
adverse effects,
analysis,
brain,
brain striatum,
brain transcriptome,
changes,
chemical,
disruptors,
dose,
effect,
evidence,
exposure,
hormone disruptors,
hormone production,
lactational exposure,
lasting changes,
low doses,
mass spectrometry,
maternal thyroid hormone production,
metabolomics,
method,
mice,
model,
mouse metabolome,
neurodevelopment,
plasma,
postnatal analysis,
production,
propylthiouracil,
pup plasma,
pups,
sequence,
signaling in vivo,
spectrometry,
striatum,
thyroid,
thyroid hormone disruptors,
thyroid hormone production,
transcriptome,
utero
