Article,
The evolving therapy of DLBCL: Bispecific antibodies
Contributors
Hutchings, Martin
0000-0003-3873-1741
(Corresponding author)
[1]
Affiliations
- [1] Rigshospitalet [NORA names: Capital Region of Denmark; Hospital; Denmark; Europe, EU; Nordic; OECD]
Abstract
Bispecific antibodies have been successfully introduced into the management of relapsed or refractory B-cell lymphomas, including DLBCL. Phase 1 studies of the different CD3/CD20 bispecifics have shown manageable safety profile and promising activity in a range of B-cell lymphomas, and recent phase 2 studies confirm the favourable safety and show frequent and durable complete responses even in heavily pre-treated and high-risk patients. This paper discusses the future potential role of these new agents as single agents and in combinations, and their position in the current and future treatment landscape, also in relation to chimeric antigen receptor T-cell therapy.
Keywords
B cells,
B-cell lymphoma,
CD3/CD20,
DLBCL,
T-cell therapy,
activity,
agents,
antibodies,
bispecific antibodies,
bispecifics,
chimeric antigen receptor T-cell therapy,
combination,
future treatment landscape,
high-risk patients,
landscape,
lymphoma,
management,
patients,
phase,
phase 1 study,
position,
potential role,
pre-treatment,
profile,
refractory B-cell lymphoma,
response,
role,
safety,
safety profile,
study,
therapy,
treatment landscape
