open access publication

Article, 2022

Nanotechnology-Assisted Metered-Dose Inhalers (MDIs) for High-Performance Pulmonary Drug Delivery Applications

Pharmaceutical Research, ISSN 0724-8741, 1573-904X, Volume 39, 11, Pages 2831-2855, 10.1007/s11095-022-03286-y

Contributors

Kumar, Raj 0000-0002-5497-9678 (Corresponding author) [1] Mehta, Piyush [2] Shankar, Konathala Ravi [3] Rajora, Manju Amit Kumar 0000-0002-8134-7123 [4] Mishra, Yogendra Kumar 0000-0002-8786-9379 [5] Mostafavi, Ebrahim 0000-0003-3958-5002 [6] Kaushik, Ajeet Kumar 0000-0003-4206-1541 [7] [8]

Affiliations

  1. [1] University of Nebraska Medical Center
    2. [NORA names: United States; America, North; OECD];
  2. [2] Pharmaceutical Technology Center, Department of Aerosol, Zydus Life Sciences Ltd., Ahmedabad, Gujarat, India
    3. [NORA names: Miscellaneous; India; Asia, South];
  3. [3] Central University of Gujarat
    4. [NORA names: India; Asia, South];
  4. [4] All India Institute of Medical Sciences
    5. [NORA names: India; Asia, South];
  5. [5] University of Southern Denmark
    6. [NORA names: SDU University of Southern Denmark; University; Denmark; Europe, EU; Nordic; OECD];

Abstract

PurposeRespiratory disorders pose a major threat to the morbidity and mortality to public health. Here we reviewed the nanotechnology based pulmonary drug delivery using metered dose inhalers.MethodsMajor respiratory diseases such as chronic obstructive pulmonary diseases (COPD), asthma, acute lower respiratory tract infections, tuberculosis (TB) and lung cancer. At present, common treatments for respiratory disorders include surgery, radiation, immunotherapy, and chemotherapy or a combination. The major challenge is development of systemic delivery of the chemotherapeutic agents to the respiratory system. Conventional delivery of chemotherapy has various limitation and adverse side effected. Hence, targeted, and systemic delivery need to be developed. Towards this direction nanotechnology, based controlled, targeted, and systemic drug delivery systems are potential candidate to enhance therapeutic efficacy with minimum side effect. Among different route of administration, pulmonary delivery has unique benefits such as circumvents first pass hepatic metabolism and reduces dose and side effects.ResultsRespiratory disorders pose a major threat to the morbidity and mortality to public health globally. Pulmonary delivery can be achieved through various drug delivery devices such as nebulizers, dry powder inhalers, and metered dose inhalers. Among them, metered dose inhalers are the most interesting and first choice of clinician over others. This review focused on nanotechnology based pulmonary drug delivery using metered dose inhalers. This report focused on delivery of various types of therapeutics using nanocarriers such as polymeric nanoparticles and micelles, dendrimers, lipid nanocarriers such as liposomes, solid lipid nanostructures and nanostructured lipid carriers, and other using metered dose inhalers discussed comprehensively. This report provides insight about the effect of parameters of MDI such as co-solvent, propellants, actuators shape, nozzle diameters, and jet lengths, and respiratory flow rate, and particle size of co-suspension of drug on aerodynamics and lung deposition of formulation. This review also provided the insight about various metered dose inhalers market scenario and digital metered dose inhalers.ConclusionThis report concluded the clinical potential of metered dose inhalers, summary of current progress and future perspectives towards the smart digital metered dose inhalers development.

Keywords

ConclusionThis, ConclusionThis report, Future perspectives, MethodsMajor, actuator, actuator shape, acute lower respiratory tract infection, administration, adverse side, aerodynamics, agents, applications, asthma, benefits, cancer, carriers, chemotherapeutic agents, chemotherapy, chronic obstructive pulmonary disease, clinical potential, clinicians, co-solvent, combination, conventional delivery, delivery, delivery applications, delivery devices, delivery of chemotherapy, delivery system, dendrimers, development, devices, diameter, direction, disease, disorders, dose, dose inhaler, drug, drug delivery, drug delivery applications, drug delivery devices, drug delivery systems, dry powder inhaler, effect, efficacy, flow rate, formulation, health, hepatic metabolism, high performance, immunotherapy, infection, inhalation, jet, jet length, length, limitations, lipid, lipid carriers, lipid nanocarriers, lipid nanostructures, liposomes, lower respiratory tract infections, lung, lung cancer, lung deposition, market scenarios, metabolism, metered dose inhaler, metered-dose inhaler, micelles, morbidity, mortality, nanocarriers, nanoparticles, nanostructured lipid carriers, nanostructures, nanotechnology, nebulizer, nozzle, nozzle diameter, obstructive pulmonary disease, particle size, particles, perspective, polymeric nanoparticles, potential, powder inhaler, progression, propeller, public health, pulmonary delivery, pulmonary disease, pulmonary drug delivery, pulmonary drug delivery applications, radiation, rate, reduced dose, reports, respiratory disease, respiratory disorders, respiratory flow rate, respiratory system, respiratory tract infections, review, route, route of administration, scenarios, shape, side, side effects, surgery, system, systemic delivery, systemic drug delivery systems, therapeutic efficacy, therapeutics, threat, tract infections, treatment, tuberculosis, unique benefits

Funders

  • National Institute of Biomedical Imaging and Bioengineering

Data Provider: Digital Science

LINKS
-

Matching Records in NORA

SUBJECTS
+

METRICS
+