open access publication

Article, 2022

Self-propelled Janus micromotors for pH-responsive release of small molecule drug

Applied Materials Today, ISSN 2352-9415, 2352-9407, Volume 27, Page 101418, 10.1016/j.apmt.2022.101418

Contributors

Maric, Tijana 0000-0002-6847-251X (Corresponding author) [1] [2] Atladóttir, Sylvía [1] [2] Thamdrup, Lasse Højlund Eklund 0000-0002-9498-1529 [1] [2] Ilchenko, Oleksii O 0000-0002-2150-895X [1] [2] Ghavami, Mahdi 0000-0003-2965-588X [1] [2] Boisen, Anja 0000-0002-9918-6567 [1] [2]

Affiliations

  1. [1] Technical University of Denmark
    2. [NORA names: DTU Technical University of Denmark; University; Denmark; Europe, EU; Nordic; OECD];
  2. [2] The Danish National Research Foundation and Villum Foundation's Center for Intelligent Drug Delivery and Sensing Using Microcontainers and Nanomechanics (IDUN), Denmark
    3. [NORA names: Denmark; Europe, EU; Nordic; OECD]

Abstract

Oral administration of drugs has received significant attention in the last 1, 2 decades, as it is the most comfortable and painless administration route, which leads to high patient compliance. Although oral delivery of drugs shows positive effects in patients, several hurdles must be overcome such as enzymatic degradation, large pH-variations found throughout the gastrointestinal (GI) tract, and continuous mucus secretion. We have studied biocompatible non-toxic micromotors as promising man-made microdevices for targeted furosemide release. Micromotors are micro-scale autonomous entities that can perform various tasks in the GI tract as a result of their impressive motion abilities. Their directional motion makes them ideal candidates to bring the necessary drug dosage to where it is needed. Herein, the micromotors were loaded for the first time with furosemide and coated with pH-sensitive polymer Eudragit® L100 using ultrasonic spray coating technique in order to achieve targeted drug delivery and pH-responsive release. Coherent anti-Stokes Raman scattering spectroscopy (CARS) was used for visualizing drug loading efficiency on the surface of micromotors. In vitro drug release was evaluated under acidic and neutral pH chemical environments and obtained results confirm their function as pH-sensitive microdevices for a drug release.

Keywords

GI tract, Janus micromotors, L100, Raman scattering spectroscopy, ability, administration of drugs, administration route, attention, chemical environment, coating technique, coherent anti-Stokes Raman scattering spectroscopy, compliance, decades, degradation, delivery, delivery of drugs, directional motion, dosage, drug, drug delivery, drug dosage, drug loading efficiency, drug release, effect, efficiency, entities, environment, enzymatic degradation, function, furosemide, furosemide release, gastrointestinal (GI) tract, in vitro drug release, loading efficiency, microdevices, micromotors, molecule drugs, motion, motion ability, mucus secretion, oral administration, oral administration of drugs, oral delivery, oral delivery of drugs, pH variation, pH-responsive release, painless administration routes, patient compliance, patients, positive effect, release, release of small molecule drugs, results, route, scattering spectroscopy, secretion, significant attention, small molecule drugs, spectroscopy, spray coating technique, surface, targeted drug delivery, task, technique, tract, ultrasonic spray coating technique

Funders

  • Danish National Research Foundation
  • The Velux Foundations

Data Provider: Digital Science

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