open access publication

Article, 2021

Association Between Severity of COVID-19 Respiratory Disease and Risk of Obstructive Sleep Apnea

Ear, Nose & Throat Journal, ISSN 0145-5613, 1942-7522, Volume 103, 1, Pages np10-np15, 10.1177/01455613211029783

Contributors

Iannella, Giannicola 0000-0003-1781-2809 [1] Vicini, Claudio [1] [2] Lechien, Jerome Rene 0000-0002-0845-0845 [3] Ravaglia, Claudia 0000-0002-2975-7299 [1] Poletti, Venerino E 0000-0002-8634-2284 [1] [4] Di Cesare, Simona [1] Amicarelli, Elena [1] Gardelli, Lucia [1] Grosso, Carmela [1] Patacca, Aria [1] Magistrelli, Eleonora [1] De Benedetto, Michele [5] Toraldo, Domenico Maurizio 0000-0003-0023-0212 [6] Arigliani, Michele 0000-0002-5366-4594 [5] Cammaroto, Giovanni 0000-0002-1618-0048 [2] Meccariello, Giuseppe [2] De Vito, Andrea 0000-0002-9802-7716 [7] Magliulo, Giuseppe 0000-0003-3052-1969 [8] Greco, Antonio [8] de Vincentiis, Marco [8] Ralli, Massimo 0000-0001-8776-0421 [8] Pace, Annalisa [8] Montincone, Valentina [9] Maniaci, Antonino 0000-0002-1251-0185 (Corresponding author) [10] Cocuzza, Salvatore Giuseppe 0000-0002-6135-0958 [10] Seligardi, Matteo [11] Di Giacinto, Ida 0000-0002-5022-7890 [12] Corso, Ruggero Massimo 0000-0001-5446-6314 [1]

Affiliations

  1. [1] Ospedale G.B. Morgagni - L.Pierantoni
    2. [NORA names: Italy; Europe, EU; OECD];
  2. [2] University of Ferrara
    3. [NORA names: Italy; Europe, EU; OECD];
  3. [3] University of Mons
    4. [NORA names: Belgium; Europe, EU; OECD];
  4. [4] Aarhus University Hospital
    5. [NORA names: Central Denmark Region; Hospital; Denmark; Europe, EU; Nordic; OECD];
  5. [5] Ospedale Vito Fazzi
    6. [NORA names: Italy; Europe, EU; OECD];

Abstract

OBJECTIVES: The purpose of this observational retrospective study was to evaluate, in patients with a severe acute respiratory syndrome coronavirus 2 infection, the association between the severity of coronavirus disease 2019 (COVID-19) respiratory illness and the risk of infected patients to develop obstructive sleep apnea (OSA). METHODS: Ninety-six patients with confirmed COVID-19 infection were enrolled in the study. The STOP-BANG questionnaire to investigate the risk of the OSA syndrome was filled in by the patients at admission. The enrolled patients were divided into 2 groups according to the respiratory disease: group 1 (72 patients), hospitalized patients undergoing conventional oxygen therapy; group 2 (24 patients), patients requiring enhanced respiratory support. STOP-BANG results of these 2 groups were compared to observe whether patients with high OSA risk more frequently presented a severe form of COVID-19. RESULTS: 41.6% of the patients in group 2 had a STOP-BANG score between 5 and 8 (high risk of having apnea); in contrast, 20.8% of the patients in group 1 had a STOP-BANG score between 5 and 8, with a statistically significant difference between the 2 groups (P = .05). A complementary trend was observed regarding the proportion of patients in the range 0 to 2, which classifies patients at a low risk of OSA (48.6% vs 20.8% for groups 1 and 2, P = .01). CONCLUSIONS: According to our data, the chances of having a severe case of COVID-19 should be considered in patients at high risk of OSA. CURRENT KNOWLEDGE/STUDY RATIONALE: Emerging research suggests that OSA could represent a potentially important risk factor for the severe forms of COVID-19. The purpose of this observational retrospective study was to evaluate the potential association between OSA and the severity of COVID-19 disease. STUDY IMPACT: According to our data, the likelihood of contracting a severe form of COVID-19 disease should be considered in patients at high risk of OSA.

Keywords

COVID-19, COVID-19 disease, COVID-19 infection, COVID-19 respiratory disease, OSA risk, STOP-Bang questionnaire, STOP-Bang score, acute respiratory syndrome coronavirus 2 infection, admission, apnea, association, cases of COVID-19, chance, conventional oxygen therapy, coronavirus 2 infection, coronavirus disease 2019, data, differences, disease, enhanced respiratory support, factors, form, group, group 1, group 2, high OSA risk, high risk, high risk of obstructive sleep apnea, hospitalized patients, illness, infected patients, infection, likelihood, low risk, low risk of obstructive sleep apnea, observational retrospective study, obstructive sleep apnea, obstructive sleep apnea syndrome, oxygen therapy, patients, potential association, proportion, proportion of patients, questionnaire, research, respiratory disease, respiratory illness, respiratory support, results, retrospective study, risk, risk factors, risk of infection patients, risk of obstructive sleep apnea, scores, severe acute respiratory syndrome coronavirus 2 infection, severe cases, severe cases of COVID-19, severe form, severity, severity of COVID-19 disease, severity of coronavirus disease 2019, significant difference, sleep apnea, statistically, statistically significant difference, study, support, syndrome, therapy

Data Provider: Digital Science

LINKS
-

Matching Records in NORA

SUBJECTS
+

METRICS
+