open access publication

Article, 2018

The neuroanatomical and neurochemical basis of apathy and impulsivity in frontotemporal lobar degeneration

Current Opinion in Behavioral Sciences, ISSN 2352-1554, 2352-1546, Volume 22, Pages 14-20, 10.1016/j.cobeha.2017.12.015

Contributors

Passamonti, Luca 0000-0002-7937-0615 [1] [2] Lansdall, Claire J [2] Rowe, James Benedict 0000-0001-7216-8679 [2] [3] [4]

Affiliations

  1. [1] Institute of Molecular Bioimaging and Physiology
    2. [NORA names: Italy; Europe, EU; OECD];
  2. [2] University of Cambridge
    3. [NORA names: United Kingdom; Europe, Non-EU; OECD];
  3. [3] MRC Cognition and Brain Sciences Unit
    4. [NORA names: United Kingdom; Europe, Non-EU; OECD];
  4. [4] University of Copenhagen
    5. [NORA names: KU University of Copenhagen; University; Denmark; Europe, EU; Nordic; OECD]

Abstract

Apathy and impulsivity are common and often coexistent consequences of frontotemporal lobar degeneration (FTLD). They increase patient morbidity and carer distress, but remain under-estimated and poorly treated. Recent trans-diagnostic approaches that span the spectrum of clinical presentations of FTLD and parkinsonism, indicate that apathy and impulsivity can be fractionated into multiple neuroanatomical and pharmacological systems. These include ventral/dorsal fronto-striatal circuits for reward-sensitivity, response-inhibition, and decision-making; moderated by noradrenaline, dopamine, and serotonin. Improved assessment tools, formal models of cognition and behavior, combined with brain imaging and psycho-pharmacology, are creating new therapeutic targets and establishing principles for stratification in future clinical trials.

Keywords

Parkinson, apathy, approach, assessment, assessment tool, basis, behavior, brain, brain imaging, carer distress, carers, circuit, clinical presentations of frontotemporal lobar degeneration, clinical trials, cognition, decision-making, degeneration, distress, dopamine, fronto-striatal circuits, frontotemporal lobar degeneration, images, impulse, increased patient morbidity, model, models of cognition, morbidity, neurochemical basis, noradrenaline, patient morbidity, pharmacological systems, psycho-pharmacology, response-inhibition, reward sensitivity, serotonin, spectra, stratification, system, target, therapeutic target, tools, trans-diagnostic approach, trials, under-estimation

Funders

  • Medical Research Council
  • Wellcome Trust

Data Provider: Digital Science

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