Article,
Loading of Drug‐Polymer Matrices in Microreservoirs for Oral Drug Delivery
Affiliations
- [1] Technical University of Denmark [NORA names: DTU Technical University of Denmark; University; Denmark; Europe, EU; Nordic; OECD]
Abstract
For major advances in microfabricated drug delivery systems (DDS), fabrication methods with high throughput using biocompatible polymers are required. Once these DDS are fabricated, loading of drug poses a significant challenge. Here, hot punching is presented as an innovative method for drug loading in microfabricated DDS. The microfabricated DDS are microcontainers fabricated in photoresist SU‐8 and biopolymer poly‐ l ‐lactic‐acid (PLLA). Furosemide (F) drug is embedded in poly‐ε‐caprolactone (PCL) polymer matrix. This F‐PCL drug polymer matrix is loaded in SU‐8 and PLLA microcontainers using hot punching with >99% yield. Thus, it is illustrated that hot punching allows high‐throughput, parallel loading of 3D polymer microcontainers with drug‐polymer matrices in a single process step. image