Article, 2016

Alterations in pain responsiveness and serum biomarkers in juvenile myoclonic epilepsy: an age- and gender-matched controlled pilot study

Future Neurology, ISSN 1748-6971, 1479-6708, Volume 11, 1, Pages 33-46, 10.2217/fnl.16.1

Contributors

Jakobsen, Lydia Anja [1] Karshenas, Ali [2] Bach, Flemming Winther 0000-0002-2518-9335 [2] Gazerani, Parisa 0000-0003-0109-3600 (Corresponding author) [1]

Affiliations

  1. [1] Aalborg University
    2. [NORA names: AAU Aalborg University; University; Denmark; Europe, EU; Nordic; OECD];
  2. [2] Aalborg University Hospital
    3. [NORA names: North Denmark Region; Hospital; Denmark; Europe, EU; Nordic; OECD]

Abstract

Introduction: Serum levels of several biomarkers along with sensory responsiveness were investigated in juvenile myoclonic epilepsy patients in comparison with healthy controls. Methods: Ten epileptic patients (36.1 3.4 years) and ten gender- and age-matched healthy controls were recruited. Mechanical sensitivity, cold pressor tolerance and serum levels of BDNF, CGRP, PGE2, S100B and TNF- were investigated. Results: Mechanical sensitivity to pinprick was lower in patients (p < 0.05) while cold pain tolerance threshold was higher. Serum level of BDNF was higher in patients compared with controls (p < 0.01). The same pattern was evident for CGRP (p < 0.05). Serum level of PGE2 was lower in patients (p < 0.01). Conclusion: Juvenile myoclonic epilepsy patients had an altered serum biomarker pattern and sensory perception in comparison with controls.

Keywords

BDNF, CGRP, PGE2, S100B, TNF, alterations, biomarker patterns, biomarkers, cold pressor tolerance, comparison, control, epilepsy, epilepsy patients, epileptic patients, gender, healthy controls, juvenile myoclonic epilepsy, juvenile myoclonic epilepsy patients, levels, levels of BDNF, levels of PGE2, mechanical sensitivity, myoclonic epilepsy, pain, pain response, pain tolerance threshold, patients, patterns, perception, pilot study, pinprick, response, sensitivity, sensory perception, sensory responses, serum, serum biomarker patterns, serum biomarkers, serum levels, serum levels of BDNF, serum levels of PGE2, study, threshold, tolerance, tolerance threshold

Funders

  • Aalborg University Hospital

Data Provider: Digital Science

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