Application
PRODUCTION OF HETERODIMERIC PROTEINS
Applicants
- Genmab (Denmark)
[NORA names: Genmab; Private Research; Denmark; Europe, EU; Nordic; OECD]
Abstract
To provide in vitro methods for producing heterodimeric proteins such as bispecific antibodies.SOLUTION: The invention provides an in vitro method for producing a heterodimeric protein comprising: providing two homodimeric proteins comprising immunoglobulin Fc regions where the heterodimeric interaction is stronger than the homodimeric interaction, for example, a first homodimeric protein has Arg at position 409 and a second homodimeric protein has Leu at position 405; and reducing the inter-chain disulfide bonds in the hinge regions of the two homodimeric proteins with 2-mercaptoethylamine or the like, and then oxidizing them under specific conditions.SELECTED DRAWING: None
Patent Family Records (45)
Production of heterodimeric proteins
Jian Mabao GRAMER MICHAEL, P. Palen, P. Van Bouquel, (...more)
2024, CN-110964115-B
PRODUCTION OF HETERODIMERIC PROTEINS
Genmab (Denmark), Genmab AS GRAMER MICHAEL, PARREN PAUL, VAN BERKEL PATRICK, (...more)
2023, US-20230227495-A1
In vitro method for producing a full-length bispecific antibody
GENMAB AS, Genmab (Denmark) KUNDU AMITAVA, PRIEM PATRICK, PATRICK VAN BERKEL, (...more)
2023, BR-112014010023-B1
Production of heterodimeric proteins
Genmab (Denmark), Genmab AS GRAMER MICHAEL, PARREN PAUL, VAN BERKEL PATRICK, (...more)
2022, US-11492371-B2
Production of heterodimeric proteins
GENMAB AS, Genmab (Denmark)
2022, IL-282393-B
PRODUCTION OF HETERODIMERIC PROTEINS
GENMAB AS, Genmab (Denmark)
2021, IL-282393-A
Production of heterodimeric proteins
GENMAB AS, Genmab (Denmark)
2021, IL-232022-B
Production of heterodimeric proteins
Genmab (Denmark), Genmab AS GRAMER MICHAEL, PARREN PAUL, VAN BERKEL PATRICK, (...more)
2021, AU-2020200496-B2
PRODUCTION OF HETERODIMERIC PROTEINS
Genmab (Denmark), Genmab AS GRAMER MICHAEL, PARREN PAUL, VAN BERKEL PATRICK, (...more)
2020, US-20200048304-A1
PRODUCTION OF HETERODIMERIC PROTEINS
GENMAB AS, Genmab (Denmark) GRAMER MICHAEL, PARREN PAUL, VAN BERKEL PATRICK, (...more)
2020, PL-2771364-T3
Creation of heterodimer proteins
Genmab (Denmark), Genmab AS クンドゥ,アミタバ, グラマー,マイケル, ゲリトセン,アーノウト, (...more)
2020, JP-6797169-B2
Heterodimeric protein production
Genmab (Denmark), Genmab AS GRAMER MICHAEL, PARREN PAUL, VAN BERKEL PATRICK, (...more)
2020, ES-2739808-T3
PRODUCTION OF HETERODIMERIC PROTEINS
Genmab (Denmark), Genmab AS GRAMER MICHAEL, VAN BERKEL PATRICK, VOS WERNER L, (...more)
2020, EP-3674320-A3
PRODUCTION OF HETERODIMERIC PROTEINS
Genmab (Denmark), Genmab AS GRAMER MICHAEL, VAN BERKEL PATRICK, VOS WERNER L, (...more)
2020, EP-3674320-A2
Production of heterodimeric proteins
Genmab (Denmark), Genmab AS GRAMER MICHAEL, PARREN PAUL, VAN BERKEL PATRICK, (...more)
2020, CN-110964115-A
Production of heterodimeric proteins
Jianma Bao GRAMER MICHAEL, P. Palen, P. Van Bouquel, (...more)
2020, CN-104114579-B
Production of heterodimeric proteins
Genmab (Denmark), Genmab AS GRAMER MICHAEL, PARREN PAUL, VAN BERKEL PATRICK, (...more)
2020, AU-2020200496-A1
Production of heterodimeric proteins
Genmab (Denmark), Genmab AS GRAMER MICHAEL, PARREN PAUL, VAN BERKEL PATRICK, (...more)
2019, US-10344050-B2
PRODUCTION OF HETERODIMERIC PROTEINS
GENMAB AS, Genmab (Denmark) GRAMER MICHAEL, PARREN PAUL, VAN BERKEL PATRICK, (...more)
2019, SI-2771364-T1
PRODUCTION OF HETERODIMERIC PROTEINS
GENMAB AS, Genmab (Denmark) GRAMER MICHAEL, PARREN PAUL, VAN BERKEL PATRICK, (...more)
2019, RS-59166-B1
PRODUCTION OF HETERODIMERIC PROTEINS
GENMAB AS, Genmab (Denmark) MICHAEL GRAMER, PAUL PARREN, PATRICK VAN BERKEL, (...more)
2019, PT-2771364-T
PRODUCTION OF HETERODIMERIC PROTEINS
GENMAB AS, Genmab (Denmark) GRAMER MICHAEL, PARREN PAUL, VAN BERKEL PATRICK, (...more)
2019, LT-2771364-T
PRODUCTION OF HETERODIMERIC PROTEINS
젠맵 에이/에스 クンドゥ,アミタバ, グラマー,マイケル, ゲリトセン,アーノウト, (...more)
2019, KR-102049803-B1
Production of heterodimeric protein
Genmab (Denmark), Genmab AS クンドゥ,アミタバ, グラマー,マイケル, ゲリトセン,アーノウト, (...more)
2019, JP-6475017-B2
PRODUCTION OF HETERODIMERIC PROTEINS
Genmab (Denmark), Genmab AS MICHAEL GRAMER, PARREN PAUL, PATRICK VAN BERKEL, (...more)
2019, JP-2019065014-A
PRODUCTION OF HETERODIMERIC PROTEINS
GENMAB AS, Genmab (Denmark) GRAMER MICHAEL, PARREN PAUL, VAN BERKEL PATRICK, (...more)
2019, HU-E044633-T2
PRODUCTION OF HETERODIMERIC PROTEINS
GENMAB AS, Genmab (Denmark) GRAMER MICHAEL, PARREN PAUL, VAN BERKEL PATRICK, (...more)
2019, HR-P20191337-T1
PRODUCTION OF HETERODIMERIC PROTEINS
Genmab (Denmark), Genmab AS GRAMER MICHAEL, PARREN PAUL, VAN BERKEL PATRICK, (...more)
2019, EP-2771364-B1
PREPARATION OF HETERODIMERED PROTEINS
GENMAB AS, Genmab (Denmark) PARREN PAUL, LABRIJN ARAN FRANK, MEESTERS JOYCE I, (...more)
2019, DK-2771364-T3
Production of heterodimeric proteins
Genmab (Denmark), Genmab AS GRAMER MICHAEL, PARREN PAUL, VAN BERKEL PATRICK, (...more)
2019, AU-2017261467-B9
Production of heterodimeric proteins
Genmab (Denmark), Genmab AS GRAMER MICHAEL, PARREN PAUL, VAN BERKEL PATRICK, (...more)
2019, AU-2017261467-B2
PRODUCTION OF HETERODIMERIC PROTEINS
GENMAB AS, Genmab (Denmark) GRAMER MICHAEL, PARREN PAUL, VAN BERKEL PATRICK, (...more)
2018, SG-10201805291T-A
in vitro method for the production of a heterodimeric protein, and nucleotide sequence
GENMAB AS, Genmab (Denmark) AMITAVA KUNDU, PATRICK PRIEM, PATRICK VAN BERKEL, (...more)
2017, BR-112014010023-A2
Production of heterodimeric proteins
Genmab (Denmark), Genmab AS GRAMER MICHAEL, PARREN PAUL, VAN BERKEL PATRICK, (...more)
2017, AU-2017261467-A1
PRODUCTION OF HETERODIMERIC PROTEINS
GENMAB A S GRAMER MICHAEL, PARREN PAUL, BERKEL PATRICK VAN, (...more)
2015, IN-2014CN03887-A
PRODUCTION OF HETERODIMERIC PROTEINS
GENMAB AS, Genmab (Denmark) GRAMER MICHAEL, PARREN PAUL, BERKEL PATRICK VAN, (...more)
2015, HK-1201540-A1
PRODUCTION OF HETERODIMERIC PROTEINS
Genmab (Denmark), Genmab AS GRAMER MICHAEL, PARREN PAUL, VAN BERKEL PATRICK, (...more)
2014, US-20140303356-A1
PRODUCTION OF HETERODIMERIC PROTEINS
GENMAB AS, Genmab (Denmark) GRAMER MICHAEL, PARREN PAUL, VAN BERKEL PATRICK, (...more)
2014, SG-11201401422V-A
PRODUCTION OF HETERODIMERIC PROTEINS
GENMAB A, Genmab (Denmark) GRAMER MICHAEL, PARREN PAUL, VAN BERKEL PATRICK, (...more)
2014, KR-20140091014-A
Production of heterodimeric protein
Genmab (Denmark), Genmab AS クンドゥ,アミタバ, グラマー,マイケル, ゲリトセン,アーノウト, (...more)
2014, JP-2014530891-A
PRODUCTION OF HETERODIMERIC PROTEINS
Genmab (Denmark), Genmab AS GRAMER MICHAEL, PARREN PAUL, VAN BERKEL PATRICK, (...more)
2014, EP-2771364-A2
Production of heterodimeric proteins
Genmab (Denmark), Genmab AS GRAMER MICHAEL, PARREN PAUL, VAN BERKEL PATRICK, (...more)
2014, CN-104114579-A
Production of heterodimeric proteins
Genmab (Denmark), Genmab AS GRAMER MICHAEL, PARREN PAUL, VAN BERKEL PATRICK, (...more)
2014, AU-2012328322-A1
PRODUCTION OF HETERODIMERIC PROTEINS
GENMAB AS, GERRITSEN ARNOUT, GRAMER MICHAEL, Genmab (Denmark), KUNDU AMITAVA, LABRIJN ARAN FRANK, MEESTERS JOYCE I, NEIJSSEN JOOST J, PARREN PAUL, PRIEM PATRICK, SCHUURMAN JANINE, VAN BERKEL PATRICK, VAN DEN BREMER EWALD T J, VAN KAMPEN MURIEL, VOS WERNER L GRAMER MICHAEL, PARREN PAUL, VAN BERKEL PATRICK, (...more)
2013, WO-2013060867-A3
PRODUCTION OF HETERODIMERIC PROTEINS
GENMAB AS, GERRITSEN ARNOUT, GRAMER MICHAEL, Genmab (Denmark), KUNDU AMITAVA, LABRIJN ARAN FRANK, MEESTERS JOYCE I, NEIJSSEN JOOST J, PARREN PAUL, PRIEM PATRICK, SCHUURMAN JANINE, VAN BERKEL PATRICK, VAN DEN BREMER EWALD T J, VAN KAMPEN MURIEL, VOS WERNER L GRAMER MICHAEL, PARREN PAUL, VAN BERKEL PATRICK, (...more)
2013, WO-2013060867-A2