Application

PRODUCTION OF HETERODIMERIC PROTEINS

Patent Number JP-2019065014-A

Publication Year 2019

Application Year 2018

Priority Year 2011

Jurisdiction JP

Status Granted

Inventors

MICHAEL GRAMER PARREN PAUL PATRICK VAN BERKEL WERNER L VOS ARNOUT GERRITSEN AMITAVA KUNDU EWALD T J VAN DEN BREMER MURIEL VAN KAMPEN PATRICK PRIEM ARAN FRANK LABRIJN JOYCE I MEESTERS JOOST J NEIJSSEN JANINE SCHUURMAN

Applicants

  1. Genmab (Denmark)
  2. [NORA names: Genmab; Private Research; Denmark; Europe, EU; Nordic; OECD]

Abstract

To provide in vitro methods for producing heterodimeric proteins such as bispecific antibodies.SOLUTION: The invention provides an in vitro method for producing a heterodimeric protein comprising: providing two homodimeric proteins comprising immunoglobulin Fc regions where the heterodimeric interaction is stronger than the homodimeric interaction, for example, a first homodimeric protein has Arg at position 409 and a second homodimeric protein has Leu at position 405; and reducing the inter-chain disulfide bonds in the hinge regions of the two homodimeric proteins with 2-mercaptoethylamine or the like, and then oxidizing them under specific conditions.SELECTED DRAWING: None

Patent Family Records (45)

Production of heterodimeric proteins  

Jian Mabao GRAMER MICHAEL, P. Palen, P. Van Bouquel, (...more)

2024, CN-110964115-B

PRODUCTION OF HETERODIMERIC PROTEINS  

Genmab (Denmark), Genmab AS GRAMER MICHAEL, PARREN PAUL, VAN BERKEL PATRICK, (...more)

2023, US-20230227495-A1

In vitro method for producing a full-length bispecific antibody  

GENMAB AS, Genmab (Denmark) KUNDU AMITAVA, PRIEM PATRICK, PATRICK VAN BERKEL, (...more)

2023, BR-112014010023-B1

Production of heterodimeric proteins  

Genmab (Denmark), Genmab AS GRAMER MICHAEL, PARREN PAUL, VAN BERKEL PATRICK, (...more)

2022, US-11492371-B2

Production of heterodimeric proteins  

GENMAB AS, Genmab (Denmark)

2022, IL-282393-B

PRODUCTION OF HETERODIMERIC PROTEINS  

GENMAB AS, Genmab (Denmark)

2021, IL-282393-A

Production of heterodimeric proteins  

GENMAB AS, Genmab (Denmark)

2021, IL-232022-B

Production of heterodimeric proteins  

Genmab (Denmark), Genmab AS GRAMER MICHAEL, PARREN PAUL, VAN BERKEL PATRICK, (...more)

2021, AU-2020200496-B2

PRODUCTION OF HETERODIMERIC PROTEINS  

Genmab (Denmark), Genmab AS GRAMER MICHAEL, PARREN PAUL, VAN BERKEL PATRICK, (...more)

2020, US-20200048304-A1

PRODUCTION OF HETERODIMERIC PROTEINS  

GENMAB AS, Genmab (Denmark) GRAMER MICHAEL, PARREN PAUL, VAN BERKEL PATRICK, (...more)

2020, PL-2771364-T3

Creation of heterodimer proteins  

Genmab (Denmark), Genmab AS クンドゥ,アミタバ, グラマー,マイケル, ゲリトセン,アーノウト, (...more)

2020, JP-6797169-B2

Heterodimeric protein production  

Genmab (Denmark), Genmab AS GRAMER MICHAEL, PARREN PAUL, VAN BERKEL PATRICK, (...more)

2020, ES-2739808-T3

PRODUCTION OF HETERODIMERIC PROTEINS  

Genmab (Denmark), Genmab AS GRAMER MICHAEL, VAN BERKEL PATRICK, VOS WERNER L, (...more)

2020, EP-3674320-A3

PRODUCTION OF HETERODIMERIC PROTEINS  

Genmab (Denmark), Genmab AS GRAMER MICHAEL, VAN BERKEL PATRICK, VOS WERNER L, (...more)

2020, EP-3674320-A2

Production of heterodimeric proteins  

Genmab (Denmark), Genmab AS GRAMER MICHAEL, PARREN PAUL, VAN BERKEL PATRICK, (...more)

2020, CN-110964115-A

Production of heterodimeric proteins  

Jianma Bao GRAMER MICHAEL, P. Palen, P. Van Bouquel, (...more)

2020, CN-104114579-B

Production of heterodimeric proteins  

Genmab (Denmark), Genmab AS GRAMER MICHAEL, PARREN PAUL, VAN BERKEL PATRICK, (...more)

2020, AU-2020200496-A1

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Genmab (Denmark), Genmab AS GRAMER MICHAEL, PARREN PAUL, VAN BERKEL PATRICK, (...more)

2019, US-10344050-B2

PRODUCTION OF HETERODIMERIC PROTEINS  

GENMAB AS, Genmab (Denmark) GRAMER MICHAEL, PARREN PAUL, VAN BERKEL PATRICK, (...more)

2019, SI-2771364-T1

PRODUCTION OF HETERODIMERIC PROTEINS  

GENMAB AS, Genmab (Denmark) GRAMER MICHAEL, PARREN PAUL, VAN BERKEL PATRICK, (...more)

2019, RS-59166-B1

PRODUCTION OF HETERODIMERIC PROTEINS  

GENMAB AS, Genmab (Denmark) MICHAEL GRAMER, PAUL PARREN, PATRICK VAN BERKEL, (...more)

2019, PT-2771364-T

PRODUCTION OF HETERODIMERIC PROTEINS  

GENMAB AS, Genmab (Denmark) GRAMER MICHAEL, PARREN PAUL, VAN BERKEL PATRICK, (...more)

2019, LT-2771364-T

PRODUCTION OF HETERODIMERIC PROTEINS  

젠맵 에이/에스 クンドゥ,アミタバ, グラマー,マイケル, ゲリトセン,アーノウト, (...more)

2019, KR-102049803-B1

Production of heterodimeric protein  

Genmab (Denmark), Genmab AS クンドゥ,アミタバ, グラマー,マイケル, ゲリトセン,アーノウト, (...more)

2019, JP-6475017-B2

PRODUCTION OF HETERODIMERIC PROTEINS

Genmab (Denmark), Genmab AS MICHAEL GRAMER, PARREN PAUL, PATRICK VAN BERKEL, (...more)

2019, JP-2019065014-A

PRODUCTION OF HETERODIMERIC PROTEINS  

GENMAB AS, Genmab (Denmark) GRAMER MICHAEL, PARREN PAUL, VAN BERKEL PATRICK, (...more)

2019, HU-E044633-T2

PRODUCTION OF HETERODIMERIC PROTEINS  

GENMAB AS, Genmab (Denmark) GRAMER MICHAEL, PARREN PAUL, VAN BERKEL PATRICK, (...more)

2019, HR-P20191337-T1

PRODUCTION OF HETERODIMERIC PROTEINS  

Genmab (Denmark), Genmab AS GRAMER MICHAEL, PARREN PAUL, VAN BERKEL PATRICK, (...more)

2019, EP-2771364-B1

PREPARATION OF HETERODIMERED PROTEINS  

GENMAB AS, Genmab (Denmark) PARREN PAUL, LABRIJN ARAN FRANK, MEESTERS JOYCE I, (...more)

2019, DK-2771364-T3

Production of heterodimeric proteins  

Genmab (Denmark), Genmab AS GRAMER MICHAEL, PARREN PAUL, VAN BERKEL PATRICK, (...more)

2019, AU-2017261467-B9

Production of heterodimeric proteins  

Genmab (Denmark), Genmab AS GRAMER MICHAEL, PARREN PAUL, VAN BERKEL PATRICK, (...more)

2019, AU-2017261467-B2

PRODUCTION OF HETERODIMERIC PROTEINS  

GENMAB AS, Genmab (Denmark) GRAMER MICHAEL, PARREN PAUL, VAN BERKEL PATRICK, (...more)

2018, SG-10201805291T-A

in vitro method for the production of a heterodimeric protein, and nucleotide sequence  

GENMAB AS, Genmab (Denmark) AMITAVA KUNDU, PATRICK PRIEM, PATRICK VAN BERKEL, (...more)

2017, BR-112014010023-A2

Production of heterodimeric proteins  

Genmab (Denmark), Genmab AS GRAMER MICHAEL, PARREN PAUL, VAN BERKEL PATRICK, (...more)

2017, AU-2017261467-A1

PRODUCTION OF HETERODIMERIC PROTEINS  

GENMAB A S GRAMER MICHAEL, PARREN PAUL, BERKEL PATRICK VAN, (...more)

2015, IN-2014CN03887-A

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2015, HK-1201540-A1

PRODUCTION OF HETERODIMERIC PROTEINS  

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2014, US-20140303356-A1

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2014, SG-11201401422V-A

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GENMAB A, Genmab (Denmark) GRAMER MICHAEL, PARREN PAUL, VAN BERKEL PATRICK, (...more)

2014, KR-20140091014-A

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2014, JP-2014530891-A

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2014, EP-2771364-A2

Production of heterodimeric proteins  

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2013, WO-2013060867-A3

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2013, WO-2013060867-A2

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