DIAGNOSIS OF TUBERCULOSIS IN SALIVA

Patent Number: WO-2024094858-A1

Publication Year: 2024

Application Year: 2023

Priority Year: 2022

Jurisdictions: WO

Status: N/A

Inventors:

VANDSØ PETERSEN KAMILLA Wejse, Christian Morberg 0000-0002-2534-2942 Knudsen, Birgitta Ruth 0000-0002-3484-3802

Applicants:

  1. Aarhus University
    2. [NORA names: AU Aarhus University; University; Denmark; Europe, EU; Nordic; OECD]
  2. Central Denmark Region
    3. [NORA names: Central Denmark Region; Hospital; Denmark; Europe, EU; Nordic; OECD]
  3. VPCIR COM APS
  4. REGION MIDTJYLLAND
    5. [NORA names: Central Denmark Region; Hospital]
  5. UNIV AARHUS
    6. [NORA names: AU Aarhus University; University]

Abstract

The present invention relates to diagnosis of tuberculosis in saliva. In particular, the present invention relates to a method for determining whether a subject is likely to be infected with Mycobacterium tuberculosis (mt) by incubating a saliva sample from a subject with a single stranded DNA oligonucleotide comprising an STS binding element for mt DNA Topoisomerase I enzyme (mTOPI) and subsequently determining the level of circularized oligonucleotide. Furthermore, the present invention relates to oligonucleotides comprising an STS binding element and uses thereof.

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DIAGNOSIS OF TUBERCULOSIS IN SALIVA

Aarhus University, Central Denmark Region, REGION MIDTJYLLAND, UNIV AARHUS, VPCIR COM APS VANDSØ PETERSEN KAMILLA, Wejse, Christian Morberg, Knudsen, Birgitta Ruth

2024, WO-2024094858-A1

Data Provider: Digital Science

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